Journal article
Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
Heart rhythm, Vol.3(7), pp.808-812
2006
DOI: 10.1016/j.hrthm.2006.03.002
PMID: 16818212
Abstract
Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS).
The purpose of this study was to examine the association between polymorphisms of ACE and eNOS gene complexes and AF in an unselected series of patients with congestive heart failure (CHF).
In each of the 340 unselected, unrelated patients with CHF, common polymorphisms in ACE (I/D) and eNOS (T786C, G894T, and intron 4b/a) gene complexes were evaluated. Associations between individual genotypes and the presence of AF were assayed.
AF was present in 51 patients (15%) and was significantly associated with the ACE D/D (odds ratio 1.5) and eNOS 894 T/T genotypes (odds ratio 3.2). There were no significant associations between AF and eNOS 786 or eNOS intron 4 genotypes.
In patients with CHF, the presence of AF was significantly associated with certain ACE and eNOS genotypes.
Details
- Title: Subtitle
- Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
- Creators
- Maninder BediDennis McNamaraBarry LondonDavid Schwartzman
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.3(7), pp.808-812
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.hrthm.2006.03.002
- PMID
- 16818212
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Language
- English
- Date published
- 2006
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984025440302771
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