Journal article
Genetic thrombophilia in patients with VTE in eastern mediterranean located tertiary care center; is it time to change the algorithm for thrombophilia work up decision making?
Journal of thrombosis and thrombolysis, Vol.21(3), pp.267-270
06/2006
DOI: 10.1007/s11239-006-5537-1
PMID: 16683219
Abstract
Background: Genetic thrombophilia work up performance is subject to debate because of the utility of the information it provides regarding prognosis of recurrence of venous thromboembolism (VTE) and guidance of duration of therapy with anticoagulation. Certain algorithms have been locally developed to guide decision making process to increase the yield of thrombophilia work up. These algorithms are not based on locally derived data. Data from the Eastern Mediterranean area (Lebanon) have shown high prevalence of thrombophilia mutations. Therefore the aim of this study was to describe the experience of a tertiary care center in thrombophilia work up among patients diagnosed with VTE.Methods: A retrospective chart analysis of the cases diagnosed with pulmonary embolism or deep venous thrombosis with radiological confirmation.Results: A total of 133 patients' charts were reviewed, 27 patients had thrombophilia work up performed, 56% had heterozygous MTHFR mutation, 44% were heterozygous for the Factor V Leiden mutation and 3.2% were found to have Factor II heterozygous mutations, and a total of 33.3% of patients had more than one genetic mutation. The common causes of provoked VTE were 59.53% malignancy, 22.64% post surgery, 12.98% bed ridden patients, and 4.85% oral contraceptive pills. Only 14% of patients with a malignancy who presented with VTE where receiving prophylactic heparin.Discussion: Doubly heterozygous prothrombotic genetic mutations are commonly present among Eastern Mediterranean patients with VTE. A prospective study to determine the predictive (negative and positive) power of the currently followed algorithm for genetic thrombophilia work up remains of significant importance. Stressing the favorable role of VTE prophylaxis among patients suffering from malignancies remains a target for raising awareness among oncologists.
Details
- Title: Subtitle
- Genetic thrombophilia in patients with VTE in eastern mediterranean located tertiary care center; is it time to change the algorithm for thrombophilia work up decision making?
- Creators
- H Isma’eel - American University of Beirut Medical Center BeirutR Accaoui - American University of Beirut Medical Center BeirutW Shamseddeen - American University of Beirut Medical Center BeirutA Taher - American University of Beirut Medical Center BeirutS Alam - American University of Beirut Medical Center BeirutR Mahfouz - American University of Beirut Medical Center BeirutM Arnaout - American University of Beirut Medical Center Beirut
- Resource Type
- Journal article
- Publication Details
- Journal of thrombosis and thrombolysis, Vol.21(3), pp.267-270
- Publisher
- Kluwer Academic Publishers
- DOI
- 10.1007/s11239-006-5537-1
- PMID
- 16683219
- ISSN
- 0929-5305
- eISSN
- 1573-742X
- Language
- English
- Date published
- 06/2006
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094322202771
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