Journal article
Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia
The world journal of biological psychiatry, Vol.16(6), pp.430-440
01/01/2015
DOI: 10.3109/15622975.2015.1062915
PMCID: PMC4795983
PMID: 26249676
Abstract
Objectives. Schizophrenia is a highly disabling psychiatric disorder with a heterogeneous phenotypic appearance. We aimed to further the understanding of some of the underlying genetics of schizophrenia, using left superior temporal gyrus (STG) grey matter thickness reduction as an endophenoptype in a genome-wide association (GWA) study. Methods. Structural magnetic resonance imaging (MRI) and genetic data of the Mind Clinical Imaging Consortium (MCIC) study of schizophrenia were used to analyse the interaction effects between 1,067,955 single nucleotide polymorphisms (SNPs) and disease status on left STG thickness in 126 healthy controls and 113 patients with schizophrenia. We next used a pathway approach to detect underlying pathophysiological pathways that may be related to schizophrenia. Results. No SNP by diagnosis interaction effect reached genome-wide significance (5 x 10(-8)) in our GWA study, but 10 SNPs reached P-values less than 10(-6). The most prominent pathways included those involved in insulin, calcium, PI3K-Akt and MAPK signalling. Conclusions. Our strongest findings in the GWA study and pathway analysis point towards an involvement of glucose metabolism in left STG thickness reduction in patients with schizophrenia only. These results are in line with recently published studies, which showed an increased prevalence of psychosis among patients with metabolic syndrome-related illnesses including diabetes.
Details
- Title: Subtitle
- Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia
- Creators
- Rick P. F. Wolthusen - Harvard UniversityJohanna Hass - University of TübingenEsther Walton - King's College LondonJessica A. Turner - Georgia State UniversityVeit Roessner - Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect, D-01062 Dresden, GermanyScott R. Sponheim - Minneapolis VA Health Care SystemBeng-Choon Ho - University of IowaDaphne J. Holt - Massachusetts General HospitalRandy L. Gollub - Massachusetts General HospitalVince Calhoun - Mind Research NetworkStefan Ehrlich - Harvard University
- Resource Type
- Journal article
- Publication Details
- The world journal of biological psychiatry, Vol.16(6), pp.430-440
- Publisher
- Taylor & Francis
- DOI
- 10.3109/15622975.2015.1062915
- PMID
- 26249676
- PMCID
- PMC4795983
- ISSN
- 1562-2975
- eISSN
- 1814-1412
- Number of pages
- 11
- Grant note
- DE-FG02-99ER62764 / Department of Energy; United States Department of Energy (DOE) Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) NARSAD Young Investigator Grant; NARSAD U24RR021992-01; NIH.NCRR MO1 RR025758-01; NIMH 1RC1MH089257 / Function BIRN 1U24; RR021382A / MIND Research Network, Morphometry Biomedical Informatics Research Network (BIRN) NIH/NCRR P41RR14075 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280868702771
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