Journal article
Genetic variants associated with patent ductus arteriosus in extremely preterm infants
Journal of perinatology, Vol.39(3), pp.401-408
03/2019
DOI: 10.1038/s41372-018-0285-6
PMCID: PMC6391165
PMID: 30518802
Abstract
Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants.
Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables.
SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnosed with PDA (p < 0.01). None of the associations were significant after correction for multiple comparisons.
We identified several common genetic variants associated with PDA. These findings may inform further studies on genetic risk factors for PDA in preterm infants.
Details
- Title: Subtitle
- Genetic variants associated with patent ductus arteriosus in extremely preterm infants
- Creators
- John M Dagle - Department of Pediatrics, University of Iowa, Iowa City, IA, USA. john-dagle@uiowa.eduKelli K Ryckman - Department of Pediatrics, University of Iowa, Iowa City, IA, USACassandra N Spracklen - Department of Genetics, University of North Carolina, Chapel Hill, NC, USAAllison M Momany - Department of Pediatrics, University of Iowa, Iowa City, IA, USAC Michael Cotten - Department of Pediatrics, Duke University, Durham, NC, USAJoshua Levy - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Durham, NC, USAGrier P Page - Social, Statistical and Environmental Sciences Unit, RTI International, Atlanta, GA, USAEdward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IA, USAWaldemar A Carlo - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USASeetha Shankaran - Department of Pediatrics, Wayne State University, Detroit, MI, USARonald N Goldberg - Duke UniversityRichard A Ehrenkranz - Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USAJon E Tyson - Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USABarbara J Stoll - Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IA, USAEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.39(3), pp.401-408
- DOI
- 10.1038/s41372-018-0285-6
- PMID
- 30518802
- PMCID
- PMC6391165
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Publisher
- United States
- Grant note
- U10 HD040492 / NICHD NIH HHS UG1 HD040492 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS R01 HL109199 / NHLBI NIH HHS UG1 HD087229 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD027880 / NICHD NIH HHS
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
- Record Identifier
- 9983996194002771
Metrics
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