Journal article
Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma
Pediatric pulmonology, Vol.44(7), pp.649-654
07/2009
DOI: 10.1002/ppul.21033
PMID: 19514054
Abstract
African Americans are disproportionately affected by asthma. Social and economic factors play a role in this disparity, but there is evidence that genetic factors may also influence the development of asthma and response to therapy in African American children. Our hypothesis is that variations in asthma related genes contribute to the observed asthma disparities by influencing the response to asthma-specific therapy. In order to test this hypothesis, we characterized the clinical response to asthma-specific therapy in 107 African American children who presented to the emergency room in status asthmaticus, with a primary outcome indicator of length of time on continuous albuterol. Single locus analysis indicated that genotype variation in glutathione-dependent S-nitrosoglutathione reductase (GSNOR) is associated with a decreased response to asthma treatment in African American children. A post hoc multi-locus analysis revealed that a combination of four single nucleotide polymorphisms (SNPs) within GSNOR, adrenergic receptor beta 2, and carbamoyl phosphate synthetase-1 give a 70% predictive value for lack of response to therapy. This predictive model needs replication in other cohorts of patients with asthma, but suggests gene-gene interactions may have greater significance than that identified with single variants. Our findings also suggest that genetic variants may contribute to the observed population disparities in asthma.
Details
- Title: Subtitle
- Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma
- Creators
- Paul E Moore - Vanderbilt UniversityKelli K RyckmanScott M WilliamsNeal PatelMarshall L SummarJames R Sheller
- Resource Type
- Journal article
- Publication Details
- Pediatric pulmonology, Vol.44(7), pp.649-654
- Publisher
- United States
- DOI
- 10.1002/ppul.21033
- PMID
- 19514054
- ISSN
- 1099-0496
- eISSN
- 1099-0496
- Grant note
- 1101 / PHS HHS U01 HL072471 / NHLBI NIH HHS UL1 RR024975 / NCRR NIH HHS 72471 / PHS HHS RR 24975 / NCRR NIH HHS
- Language
- English
- Date published
- 07/2009
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983995031402771
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