Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes

Yang Liu; Nifang Niu; Xilin Zhu; Te Du; Xin Wang; Dongmei Chen; Xiaopan Wu; Harvest F Gu; Ying Liu

doi:10.2337/db07-0008

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Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes

Journal article

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Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes

Yang Liu, Nifang Niu, Xilin Zhu, Te Du, Xin Wang, Dongmei Chen, Xiaopan Wu, Harvest F Gu and Ying Liu

Diabetes (New York, N.Y.), Vol.57(3), pp.777-782

03/01/2008

DOI: 10.2337/db07-0008

PMID: 18071027

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Abstract

Nuclear respiratory factor 1 (NRF1) is a strong biological and positional candidate to contribute to type 2 diabetes susceptibility. This study aimed at evaluating associations between NRF1 genetic polymorphisms and development of type 2 diabetes. Using a variation screening approach, 6 novel and 10 known single nucleotide polymorphisms (SNPs) in the NRF1 gene were identified. Nine SNPs were then selected using pairwise tagging with an r(2) cutoff of 0.8 and/or minor allele frequency of >5% and genotyped in 596 type 2 diabetic patients and 431 nondiabetic subjects, all of whom were Han Chinese. Two novel SNPs (-46127T>C and +98560A>G) were associated with type 2 diabetes (P = 0.018 and 0.036; for possession of minor allele, odds ratio [OR] 0.620 and 3.199, with dominant model and correction for multiple comparisons). In SNP rs1882094 (+141G>T), the nondiabetic control subjects carrying GG genotype had lower fasting plasma glucose levels than carriers with other genotypes (P = 0.0002). One common haplotype (H2) mainly composed of SNPs rs6969098 (-24833 A>G), rs1882094, and another novel variant (+97884G>A) was significantly associated with type 2 diabetes (P = 0.016, OR 0.706). Subjects with this haplotype had lower fasting triglyceride levels when compared with those with other haplotypes (P = 0.010). The present study shows an association of SNPs in the NRF1 gene with type 2 diabetes in a Han Chinese population. NRF1 genetic polymorphisms may be a suspectibility factor for type 2 diabetes by conferring abnormalities in triglyceride metabolism. Further studies should replicate this finding using larger and racially diverse populations.

Aged

Asian Continental Ancestry Group

Diabetes Mellitus, Type 2 - genetics

Female

Genetic Predisposition to Disease

Genetic Variation

Haplotypes

Humans

Male

Middle Aged

Nuclear Respiratory Factor 1 - genetics

Odds Ratio

Details

Title: Subtitle: Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes
Creators: Yang Liu - Chinese Academy of Medical Sciences & Peking Union Medical College
Nifang Niu - Chinese Academy of Medical Sciences & Peking Union Medical College
Xilin Zhu - Chinese Academy of Medical Sciences & Peking Union Medical College
Te Du
Xin Wang - Chinese Academy of Medical Sciences & Peking Union Medical College
Dongmei Chen - Chinese Academy of Medical Sciences & Peking Union Medical College
Xiaopan Wu - Chinese Academy of Medical Sciences & Peking Union Medical College
Harvest F Gu - Karolinska University Hospital
Ying Liu - Chinese Academy of Medical Sciences & Peking Union Medical College
Resource Type: Journal article
Publication Details: Diabetes (New York, N.Y.), Vol.57(3), pp.777-782
DOI: 10.2337/db07-0008
PMID: 18071027
ISSN: 0012-1797
eISSN: 1939-327X
Language: English
Date published: 03/01/2008
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics
Record Identifier: 9984701547302771

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