Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight

Gordon Worley; Stephen W Erickson; Kathryn E Gustafson; Yuliya S Nikolova; Allison E Ashley-Koch; Daniel W Belsky; Ricki F Goldstein; Grier P Page; C Michael Cotten; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network; Edward F Bell; Jeffrey C Murray

doi:10.1111/dmcn.14383

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Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight

Journal article

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Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight

Gordon Worley, Stephen W Erickson, Kathryn E Gustafson, Yuliya S Nikolova, Allison E Ashley-Koch, Daniel W Belsky, Ricki F Goldstein, Grier P Page, C Michael Cotten, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, …

Developmental medicine and child neurology, Vol.62(6), pp.750-757

06/2020

DOI: 10.1111/dmcn.14383

PMCID: PMC7200269

PMID: 31691959

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https://www.ncbi.nlm.nih.gov/pmc/articles/7200269View

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Abstract

To determine if genetic variation associated with decreased dopamine neurotransmission predicts a decrease in motor development in a convenience cohort study of infants born extremely-low-birthweight (ELBW). Four hundred and ninety-eight infants born ELBW had genome-wide genotyping and a neurodevelopmental evaluation at 18 to 22 months of age, corrected for preterm birth. A polygenic risk score (PRS) was created to combine into one predictor variable the hypothesized influences on motor development of alleles at seven independent single nucleotide polymorphisms previously associated with relative decreases in both dopamine neurotransmission and motor learning, by summing the number of alleles present in each infant (range=0-14). The motor development outcome was the Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development, Second Edition. The linear regression models were adjusted for seven clinical and four genetic ancestry covariates. The mean PRS of infants with cerebral palsy (CP) was compared to those without CP. PRS was inversely related to PDI (p=0.011). Each 1-point increase in PRS resulted in an average decrease in PDI of 1.37 points. Patients with CP did not have a greater mean PRS than those without (p=0.67), both with and without adjustment for covariates. Genetic variation that favors a decrease in dopamine neurotransmission predisposes to a decrease in motor development in infants born ELBW, but not to the diagnosis of CP. Genetic variation in dopamine neurotransmission was associated with a decrease in motor development in infants born at an extremely-low-birthweight. It does not predispose to the diagnosis of cerebral palsy.

Cohort Studies

Developmental Disabilities - genetics

Developmental Disabilities - metabolism

Dopamine - physiology

Female

Genetic Variation - genetics

Humans

Infant, Extremely Low Birth Weight

Infant, Extremely Premature

Infant, Newborn

Infant, Premature, Diseases - genetics

Male

Motor Skills Disorders - genetics

Motor Skills Disorders - metabolism

Synaptic Transmission - genetics

Details

Title: Subtitle: Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight
Creators: Gordon Worley - Duke University
Stephen W Erickson - RTI International
Kathryn E Gustafson - Duke University
Yuliya S Nikolova - Centre for Addiction and Mental Health
Allison E Ashley-Koch - Duke Medical Center
Daniel W Belsky - Duke University
Ricki F Goldstein - Duke University
Grier P Page - RTI International
C Michael Cotten - Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Edward F Bell (Contributor) - University of Iowa, Neonatology
Jeffrey C Murray (Contributor)
Resource Type: Journal article
Publication Details: Developmental medicine and child neurology, Vol.62(6), pp.750-757
DOI: 10.1111/dmcn.14383
PMID: 31691959
PMCID: PMC7200269
NLM abbreviation: Dev Med Child Neurol
ISSN: 0012-1622
eISSN: 1469-8749
Grant note: UG1 HD040492 / NICHD NIH HHS M01 RR000039 / NCRR NIH HHS U24 HD095254 / NICHD NIH HHS M01 RR000030 / NCRR NIH HHS U10 HD027871 / NICHD NIH HHS M01 RR008084 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS U01 HG004423 / NHGRI NIH HHS M01 RR016587 / NCRR NIH HHS UG1 HD027880 / NICHD NIH HHS U10 HD040498 / NICHD NIH HHS UG1 HD053109 / NICHD NIH HHS M01 RR000080 / NCRR NIH HHS M01 RR000997 / NCRR NIH HHS U10 HD021373 / NICHD NIH HHS U10 HD040492 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U10 HD040689 / NICHD NIH HHS U10 HD027904 / NICHD NIH HHS U10 HD053109 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS M01 RR000032 / NCRR NIH HHS U10 HD027856 / NICHD NIH HHS U10 HD027880 / NICHD NIH HHS U10 HD027853 / NICHD NIH HHS U10 HD021364 / NICHD NIH HHS U10 HD027851 / NICHD NIH HHS M01 RR000633 / NCRR NIH HHS M01 RR000070 / NCRR NIH HHS U10 HD034216 / NICHD NIH HHS UL1 TR001425 / NCATS NIH HHS UG1 HD040689 / NICHD NIH HHS U10 HD27871 / Eunice Kennedy Shriver National Institute of Child Health and Human Development M01 RR000750 / NCRR NIH HHS U10 HD21415 / Eunice Kennedy Shriver National Institute of Child Health and Human Development U01 HD036790 / NICHD NIH HHS M01 RR007122 / NCRR NIH HHS U10 HD021385 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS U10 HD27881 / Eunice Kennedy Shriver National Institute of Child Health and Human Development UG1 HD027853 / NICHD NIH HHS
Language: English
Date published: 06/2020
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Neonatology
Record Identifier: 9984353847202771

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