Journal article
Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight
Human molecular genetics, Vol.21(24), pp.5344-5358
12/01/2012
DOI: 10.1093/hmg/dds372
PMID: 22956269
Abstract
Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P = 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4–36 g] lower birth weight (P = 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: −4 to 14 g; P = 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight.
Details
- Title: Subtitle
- Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight
- Creators
- A.W.R TyrrellVille HuikariJason ChristieAlana CavadinoRachel BakkerMaria BrionFrank GellerLavinia PaternosterRonny MyhreCatherine PotterPaul C JohnsonShanil EbrahimBjarke FeenstraA.L HartikainenAndrew T HattersleyAlbert HofmanMarika KaakinenLynn LowePer MagnusAlex McConnachieMads MelbyeJane NgChristian NohrChristopher PowerSusan RingSylvain SebertVerena SengpielRob TaalGraham WattNaveed SattarCaroline ReltonBo JacobssonTimothy FraylingThorkild SørensenJeffrey MurrayDebbie LawlorCraig PennellVincent JaddoeElina HypponenWilliam LoweMarjo-Riitta JarvelinGeorge Davey SmithRachel Freathy
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.21(24), pp.5344-5358
- DOI
- 10.1093/hmg/dds372
- PMID
- 22956269
- NLM abbreviation
- Hum Mol Genet
- ISSN
- 0964-6906
- eISSN
- 1460-2083
- Language
- English
- Date published
- 12/01/2012
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025409102771
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