Journal article
Genetically Determined Height and Risk of Non-hodgkin Lymphoma
Frontiers in oncology, Vol.9, pp.1539-1539
2019
DOI: 10.3389/fonc.2019.01539
PMCID: PMC6999122
PMID: 32064237
Abstract
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17,
= 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31,
= 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Details
- Title: Subtitle
- Genetically Determined Height and Risk of Non-hodgkin Lymphoma
- Creators
- Amy Moore - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesEleanor Kane - Department of Health Sciences, University of York, York, United KingdomZhaoming Wang - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesOrestis A Panagiotou - Center for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI, United StatesLauren R Teras - Epidemiology Research Program, American Cancer Society, Atlanta, GA, United StatesAlain Monnereau - Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, FranceNicole Wong Doo - Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, AustraliaMitchell J Machiela - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesChristine F Skibola - Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, United StatesSusan L Slager - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United StatesGilles Salles - Equipe Experimental and Clinical Models of Lymphomagenesis, Cancer Research Center of Lyon, Institut National de Santé et de la Recherche Médicale UMR1052 Pierre Benite, Lyon, FranceNicola J Camp - Division of Hematology and Hematologic Malignancies, Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United StatesPaige M Bracci - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United StatesAlexandra Nieters - Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg im Breisgau, GermanyRoel C H Vermeulen - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, NetherlandsJoseph Vijai - Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesKarin E Smedby - Hematology Center, Karolinska University Hospital, Stockholm, SwedenYawei Zhang - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United StatesClaire M Vajdic - Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, AustraliaWendy Cozen - Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesJohn J Spinelli - School of Population and Public Health, University of British Columbia, Vancouver, BC, CanadaHenrik Hjalgrim - Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkGraham G Giles - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, AustraliaBrian K Link - Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, United StatesJacqueline Clavel - Université Paris Descartes, Paris, FranceAlan A Arslan - Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, United StatesMark P Purdue - Ontario Health Study, Toronto, ON, CanadaLesley F Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United StatesDemetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesGiovanni M Ferri - Interdisciplinary Department of Medicine, University of Bari, Bari, ItalyThomas M Habermann - Division of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United StatesHans-Olov Adami - Department of Epidemiology, Harvard School of Public Health, Boston, MA, United StatesNikolaus Becker - Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, GermanyYolanda Benavente - CIBER de Epidemiología y Salud Pública, Barcelona, SpainSimonetta Bisanzi - Regional Cancer Prevention Laboratory, Oncological Network, Prevention and Research Institute (ISPRO), Florence, ItalyPaolo Boffetta - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesPaul Brennan - International Agency for Research on Cancer (IARC), Lyon, FranceAngela R Brooks-Wilson - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaFederico Canzian - Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, GermanyLucia Conde - Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, United KingdomDavid G Cox - INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, FranceKaren Curtin - Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United StatesLenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, CzechiaSusan M Gapstur - Epidemiology Research Program, American Cancer Society, Atlanta, GA, United StatesHervé Ghesquières - Department of Hematology, Centre Léon Bérard, Lyon, FranceMartha Glenn - Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United StatesBengt Glimelius - Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenRebecca D Jackson - Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United StatesQing Lan - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesMark Liebow - Division of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United StatesMarc Maynadie - INSERM U1231, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, FranceJames McKay - International Agency for Research on Cancer (IARC), Lyon, FranceMads Melbye - Department of Medicine, Stanford University School of Medicine, Stanford, CA, United StatesLucia Miligi - Environmental and Occupational Epidemiology Unit, Oncological Network, Prevention and Research Institute (ISPRO), Florence, ItalyRoger L Milne - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, AustraliaThierry J Molina - Department of Pathology, AP-HP, Necker Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceLindsay M Morton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesKari E North - Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesKenneth Offit - Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesMarina Padoan - CPO-Piemonte and Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Piemonte Orientale, Novara, ItalyAlpa V Patel - Epidemiology Research Program, American Cancer Society, Atlanta, GA, United StatesSara Piro - Environmental and Occupational Epidemiology Unit, Oncological Network, Prevention and Research Institute (ISPRO), Florence, ItalyVignesh Ravichandran - Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesElio Riboli - School of Public Health, Imperial College London, London, United KingdomSilvia de Sanjose - CIBER de Epidemiología y Salud Pública, Barcelona, SpainRichard K Severson - Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, United StatesMelissa C Southey - Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, VIC, AustraliaAnthony Staines - School of Nursing and Human Sciences, Dublin City University, Dublin, IrelandCarolyn Stewart - Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesRuth C Travis - Cancer Epidemiology Unit, University of Oxford, Oxford, United KingdomElisabete Weiderpass - International Agency for Research on Cancer, World Health Organization, Lyon, FranceStephanie Weinstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesTongzhang Zheng - Department of Epidemiology, Brown School of Public Health, Providence, RI, United StatesStephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesNilanjan Chatterjee - Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, United StatesNathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesBrenda M Birmann - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United StatesJames R Cerhan - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United StatesSonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
- Resource Type
- Journal article
- Publication Details
- Frontiers in oncology, Vol.9, pp.1539-1539
- DOI
- 10.3389/fonc.2019.01539
- PMID
- 32064237
- PMCID
- PMC6999122
- NLM abbreviation
- Front Oncol
- ISSN
- 2234-943X
- eISSN
- 2234-943X
- Publisher
- Switzerland
- Language
- English
- Date published
- 2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984066336702771
Metrics
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