Journal article
Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses
International journal of cancer, Vol.158(1), pp.45-59
01/2026
DOI: 10.1002/ijc.70039
PMCID: PMC12588556
PMID: 40910475
Abstract
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (OR
= 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.
Details
- Title: Subtitle
- Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses
- Creators
- Amy Moore - National Cancer InstituteEleanor Kane - University of YorkLauren R Teras - American Cancer SocietyMitchell J Machiela - National Cancer InstituteJoshua Arias - National Cancer InstituteOrestis A Panagiotou - Brown UniversityAlain Monnereau - Sorbonne Paris CitéNicole Wong Doo - The University of SydneyZhaoming Wang - National Cancer InstituteSusan L Slager - Mayo Clinic in FloridaRoel C H Vermeulen - University Medical Center UtrechtClaire M Vajdic - UNSW SydneyKarin E Smedby - Karolinska University HospitalJohn J Spinelli - University of British ColumbiaJoseph Vijai - Memorial Sloan Kettering Cancer CenterGraham G Giles - Monash UniversityBrian K Link - University of IowaAlan A Arslan - New York UniversityAlexandra Nieters - University Medical Center FreiburgPaige M Bracci - University of California, San FranciscoNicola J Camp - Huntsman Cancer InstituteGilles Salles - University of British ColumbiaWendy Cozen - University of California, IrvineHenrik Hjalgrim - Statens Serum InstitutImmaculata De Vivo - Harvard UniversityHans-Olov Adami - University of OsloDemetrius Albanes - National Cancer InstituteNikolaus Becker - German Cancer Research CenterYolanda Benavente - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaSimonetta Bisanzi - Florence (Netherlands)Paolo Boffetta - Stony Brook UniversityPaul Brennan - Centre international de recherche sur le cancerAngela R Brooks-Wilson - Genome British ColumbiaFederico Canzian - German Cancer Research CenterJacqueline Clavel - InsermLucia Conde - University College LondonDavid G Cox - Centre de Recherche en Cancérologie de LyonKaren Curtin - University of UtahLenka Foretova - Masaryk Memorial Cancer InstituteHervé Ghesquières - Université Claude Bernard Lyon 1Bengt Glimelius - Uppsala UniversityThomas M Habermann - Mayo ClinicJonathan N Hofmann - National Cancer InstituteQing Lan - National Cancer InstituteMark Liebow - Mayo ClinicAnne Lincoln - University of British ColumbiaMarc Maynadie - Université de BourgogneJames McKay - Centre international de recherche sur le cancerMads Melbye - Stanford UniversityLucia Miligi - Piedmont Reference Center for Epidemiology and Cancer PreventionRoger L Milne - Cancer Council VictoriaThierry J Molina - InsermLindsay M Morton - National Cancer InstituteKari E North - University of North Carolina at Chapel HillKenneth Offit - University of British ColumbiaMarina Padoan - Università degli Studi del Piemonte Orientale “Amedeo Avogadro”Sara Piro - Piedmont Reference Center for Epidemiology and Cancer PreventionAlpa V Patel - University of British ColumbiaMark P Purdue - National Cancer InstituteVignesh Ravichandran - University of British ColumbiaElio Riboli - Imperial College LondonRichard K Severson - Wayne State UniversityMelissa C Southey - Cancer Council VictoriaAnthony Staines - Dublin City UniversityLesley F Tinker - Fred Hutch Cancer CenterRuth C Travis - University of OxfordSophia S Wang - City Of Hope National Medical CenterElisabete Weiderpass - Centre international de recherche sur le cancerStephanie Weinstein - National Cancer InstituteTongzhang Zheng - Brown UniversityStephen J Chanock - National Cancer InstituteNathaniel Rothman - Division of Cancer Epidemiology and GeneticsBrenda M Birmann - Brigham and Women's HospitalJames R Cerhan - National Cancer InstituteSonja I Berndt - National Cancer Institute
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.158(1), pp.45-59
- DOI
- 10.1002/ijc.70039
- PMID
- 40910475
- PMCID
- PMC12588556
- NLM abbreviation
- Int J Cancer
- ISSN
- 1097-0215
- eISSN
- 1097-0215
- Publisher
- WILEY
- Grant note
- NCI NIH HHS
- Language
- English
- Electronic publication date
- 09/05/2025
- Date published
- 01/2026
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984958609102771
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