Genetically modified species in research: opportunities and challenges for the histology core laboratory

Alicia K Olivier; Paul Naumann; Adam Goeken; Christine Hochstedler; Mary Sturm; Janis R Rodgers; Katherine N Gibson-Corley; David K Meyerholz

doi:10.1179/2046023612Y.0000000003

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Genetically modified species in research: opportunities and challenges for the histology core laboratory

Journal article

Peer reviewed

Genetically modified species in research: opportunities and challenges for the histology core laboratory

Alicia K Olivier, Paul Naumann, Adam Goeken, Christine Hochstedler, Mary Sturm, Janis R Rodgers, Katherine N Gibson-Corley and David K Meyerholz

Journal of histotechnology, Vol.35(2), pp.63-67

07/01/2012

DOI: 10.1179/2046023612Y.0000000003

PMCID: PMC3419433

PMID: 22904582

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https://www.ncbi.nlm.nih.gov/pmc/articles/3419433View

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Abstract

Translational research using animal models has traditionally involved genetically modified rodents; however, there is increasing use of other novel genetically engineered species. As histology laboratories interface with researchers studying these novel species there will be many situations in which protocols will need to be adapted to the species, model and research goals. This paper gives examples of protocol adaptations to meet research needs and addresses common considerations that should be addressed for all research tissues submitted to the histotechnology laboratory. Positioning the histotechnologist, as well as the investigator, to meet the challenges associated with novel research models will help maximize research efficacy and quality.

Genetically modified animals

Immunohistochemistry

Tissue embedding

Translational research

Histology

Details

Title: Subtitle: Genetically modified species in research: opportunities and challenges for the histology core laboratory
Creators: Alicia K Olivier - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Paul Naumann - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Adam Goeken - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Christine Hochstedler - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Mary Sturm - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Janis R Rodgers - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Katherine N Gibson-Corley - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
David K Meyerholz - Department of PathologyRoy J. and Lucille A. Carver College of Medicine, University of Iowa
Resource Type: Journal article
Publication Details: Journal of histotechnology, Vol.35(2), pp.63-67
DOI: 10.1179/2046023612Y.0000000003
PMID: 22904582
PMCID: PMC3419433
NLM abbreviation: J Histotechnol
ISSN: 0147-8885
eISSN: 2046-0236
Publisher: Taylor & Francis
Language: English
Date published: 07/01/2012
Academic Unit: Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9984083217402771

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