Journal article
Genetics and visceral leishmaniasis: of mice and man
Parasite immunology, Vol.31(5), pp.254-266
05/2009
DOI: 10.1111/j.1365-3024.2009.01102.x
PMCID: PMC3160815
PMID: 19388946
Abstract
Ninety percent of the 500,000 annual new cases of visceral leishmaniasis occur in India/Bangladesh/Nepal, Sudan and Brazil. Importantly, 80-90% of human infections are sub-clinical or asymptomatic, usually associated with strong cell-mediated immunity. Understanding the environmental and genetic risk factors that determine why two people with the same exposure to infection differ in susceptibility could provide important leads for improved therapies. Recent research using candidate gene association analysis and genome-wide linkage studies (GWLS) in collections of families from Sudan, Brazil and India have identified a number of genes/regions related both to environmental risk factors (e.g. iron), as well as genes that determine type 1 versus type 2 cellular immune responses. However, until now all of the allelic association studies carried out have been underpowered to find genes of small effect sizes (odds ratios or OR<2), and GWLS using multicase pedigrees have only been powered to find single major genes, or at best oligogenic control. The accumulation of large DNA banks from India and Brazil now makes it possible to undertake genome-wide asscociation studies (GWAS), which are ongoing as part of phase two of the Wellcome Trust Case Control Consortium. Data from this analysis should seed research into novel genes and mechanisms that influence susceptibility to visceral leishmaniasis.
Details
- Title: Subtitle
- Genetics and visceral leishmaniasis: of mice and man
- Creators
- J. M BLACKWELL - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAM FAKIOLA - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAM. E IBRAHIM - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAS.E JAMIESON - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAS. B JERONIMO - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAE. N MILLER - University of CambridgeA MISHRA - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAH. S MOHAMED - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAC. S PEACOCK - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAM RAJU - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAS SUNDAR - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USAM. E WILSON - Departments of Internal Medicine, Microbiology, Epidemiology and the Molecular Biology Program, University of Iowa and the VA Medical Center, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Parasite immunology, Vol.31(5), pp.254-266
- DOI
- 10.1111/j.1365-3024.2009.01102.x
- PMID
- 19388946
- PMCID
- PMC3160815
- NLM abbreviation
- Parasite Immunol
- ISSN
- 0141-9838
- eISSN
- 1365-3024
- Grant note
- P50 AI030639-17 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI076233-02 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P50 AI030639-18 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI076233-03 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P50 AI074321-03 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI076233-01A1 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P50 AI074321-04 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P50 AI030639-16 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P50 AI074321-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 05/2009
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001140602771
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