Journal article
Genetics of Event-Related Brain Potentials in Response to a Semantic Priming Paradigm in Families with a History of Alcoholism
American journal of human genetics, Vol.68(1), pp.128-135
2001
DOI: 10.1086/316936
PMCID: PMC1234905
PMID: 11102287
Abstract
Event-related brain potentials (ERPs) are altered in patients with a variety of psychiatric disorders and may represent quantitative correlates of disease liability that are more amenable to genetic analysis than disease status itself. Results of a genomewide linkage screen are presented for amplitude of the N4 and P3 components of the ERP, measured at 19 scalp locations in response to a semantic priming task for 604 individuals in 100 pedigrees ascertained as part of the Collaborative Study on the Genetics of Alcoholism. N4 and P3 amplitudes in response to three stimuli (nonwords, primed words [i.e., antonyms], and unprimed words) all showed significant heritabilities, the highest being .54. Both N4 and P3 showed significant genetic correlations across stimulus type at a given lead and across leads within a stimulus, indicating shared genetic influences among the traits. There were also substantial genetic correlations between the N4 and P3 amplitudes for a given lead, even across stimulus type. N4 amplitudes showed suggestive evidence of linkage in several chromosomal regions, and P3 amplitudes showed significant evidence of linkage to chromosome 5 and suggestive evidence of linkage to chromosome 4.
Details
- Title: Subtitle
- Genetics of Event-Related Brain Potentials in Response to a Semantic Priming Paradigm in Families with a History of Alcoholism
- Creators
- L Almasy - Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TXB Porjesz - Department of Psychiatry, SUNY Health Science Center, Brooklyn, NYJ Blangero - Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TXA Goate - Department of Psychiatry, Washington University School of Medicine, St. LouisH.J Edenberg - Department of Biochemistry and Molecular Biology andD.B Chorlian - Department of Psychiatry, SUNY Health Science Center, Brooklyn, NYS Kuperman - Department of Psychiatric Research, University of Iowa, Iowa CityS.J O’Connor - Department of Biochemistry and Molecular Biology andJ Rohrbaugh - Department of Psychiatry, Washington University School of Medicine, St. LouisL.O Bauer - Department of Psychiatry, University of Connecticut Health Center, FarmingtonT Foroud - Department of Medical and Molecular Genetics, Indiana University School of Medicine, IndianapolisJ.P Rice - Department of Psychiatry, Washington University School of Medicine, St. LouisT Reich - Department of Psychiatry, Washington University School of Medicine, St. LouisH Begleiter - Department of Psychiatry, SUNY Health Science Center, Brooklyn, NY
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.68(1), pp.128-135
- Publisher
- Elsevier Inc
- DOI
- 10.1086/316936
- PMID
- 11102287
- PMCID
- PMC1234905
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 2001
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003915302771
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