Journal article
Genetics of the dentofacial variation in human malocclusion
Orthodontics & craniofacial research, Vol.18(1), pp.91-99
04/2015
DOI: 10.1111/ocr.12083
PMCID: PMC4418210
PMID: 25865537
Abstract
Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This review summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this review will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.
Details
- Title: Subtitle
- Genetics of the dentofacial variation in human malocclusion
- Creators
- L M Moreno Uribe - Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA; Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USAS F Miller
- Resource Type
- Journal article
- Publication Details
- Orthodontics & craniofacial research, Vol.18(1), pp.91-99
- DOI
- 10.1111/ocr.12083
- PMID
- 25865537
- PMCID
- PMC4418210
- NLM abbreviation
- Orthod Craniofac Res
- ISSN
- 1601-6335
- eISSN
- 1601-6343
- Publisher
- England
- Grant note
- T32 DE014678 / NIDCR NIH HHS\nR90 DE024296 / NIDCR NIH HHS\nT32-DEO14678-09 / PHS HHS\nCDCR01D000295 / PHS HHS\nR01 DD000295 / NCBDD CDC HHS\nT90 DE023520 / NIDCR NIH HHS\n2 UL1 TR000442-06 / NCATS NIH HHS\nUL1 TR000442 / NCATS NIH HHS
- Language
- English
- Date published
- 04/2015
- Academic Unit
- Orthodontics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984065722502771
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