Journal article
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
American journal of human genetics, Vol.73(1), pp.49-62
2003
DOI: 10.1086/376547
PMCID: PMC1180589
PMID: 12802785
Abstract
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for “very narrow” (i.e., BP-I and schizoaffective disorder–BP) and “narrow” (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A “broad” model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant
P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant
P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. Relatively few BPD pedigrees have been studied under narrow disease models relative to the schizophrenia GSMA data set, which produced more significant results. There was no overlap of the highest-ranked regions for the two disorders. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.
Details
- Title: Subtitle
- Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
- Creators
- Ricardo Segurado - Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, St. James Hospital, DublinSevilla D Detera-Wadleigh - Mood and Anxiety Disorders Program, National Institute of Mental Health/National Institutes of Health, National Institutes of Health, BethesdaDouglas F Levinson - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, PhiladelphiaCathryn M Lewis - Division of Genetics and Development, Guy’s, King’s & St Thomas’ School of Medicine, University College London, LondonMichael Gill - Trinity Centre for Health Sciences, Department of Psychiatry, St. James Hospital, DublinJohn I Nurnberger - Department of Psychiatry, Indiana University, IndianapolisNick Craddock - Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Edgbaston, Birmingham, United KingdomJ. Raymond DePaulo - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BaltimoreMiron Baron - Division of Psychiatric Genetics, Department of Medical Genetics, Columbia University, New York State Psychiatric Institute, Mount Sinai School of Medicine, New YorkElliot S Gershon - Department of Psychiatry, University of Chicago, ChicagoJenny Ekholm - Department of Molecular Medicine, National Public Health Institute, and Department of Medical Genetics, University of Helsinki, National Public Health Institute, HelsinkiSven Cichon - Department of Medical Genetics Flanders Interuniversity Institute for Biotechnology, Antwerp, BelgiumGustavo Turecki - Department of Psychiatry sMcGill University, MontrealStephan Claes - Department of Psychiatry, University of Antwerp, Flanders Interuniversity Institute for Biotechnology, Antwerp, BelgiumJohn R Kelsoe - Laboratory of Psychiatric Genomics, Department of Psychiatry, University of California San Diego (UCSD), La JollaPeter R Schofield - Garvan Institute of Medical Research, Macquarie University, SydneyRenee F Badenhop - Garvan Institute of Medical Research, Macquarie University, SydneyJ Morissette - Neuroscience Centre Hospitalier de l'Université Laval Research Center and Laval University, QuebecHilary Coon - University of Utah, Salt Lake CityDouglas Blackwood - Psychiatry and Biological Sciences, University of Edinburgh, EdinburghL. Alison McInnes - Departments of Psychiatry and Human Genetics, Mount Sinai School of Medicine, New YorkTatiana Foroud - Department of Psychiatry, Indiana University, IndianapolisHoward J Edenberg - Department of Medical and Molecular Genetics, Indiana University, IndianapolisTheodore Reich - Department of Psychiatry, Washington University School of Medicine, St. LouisJohn P Rice - Department of Psychiatry, Washington University School of Medicine, St. LouisAlison Goate - Department of Psychiatry, Washington University School of Medicine, St. LouisMelvin G McInnis - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BaltimoreFrancis J McMahon - Mood and Anxiety Disorders Program, National Institute of Mental Health/National Institutes of Health, National Institutes of Health, BethesdaJudith A Badner - Department of Psychiatry, University of Chicago, ChicagoLynn R Goldin - Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, BethesdaPhil Bennett - Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Edgbaston, Birmingham, United KingdomVirginia L Willour - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BaltimorePeter P Zandi - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BaltimoreJianjun Liu - Division of Psychiatric Genetics, Department of Medical Genetics, Columbia University, New York State Psychiatric Institute, Mount Sinai School of Medicine, New YorkConrad Gilliam - Division of Psychiatric Genetics, Department of Medical Genetics, Columbia University, New York State Psychiatric Institute, Mount Sinai School of Medicine, New YorkSuh-Hang Juo - Division of Psychiatric Genetics, Department of Medical Genetics, Columbia University, New York State Psychiatric Institute, Mount Sinai School of Medicine, New YorkWade H Berrettini - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, PhiladelphiaTakeo Yoshikawa - Laboratory for Molecular Psychiatry, RIKEN (Institute of Physical and Chemical Research) Brain Science Institute, Saitama, JapanLeena Peltonen - Department of Molecular Medicine, National Public Health Institute, and Department of Medical Genetics, University of Helsinki, National Public Health Institute, HelsinkiJouko Lönnqvist - Department of Mental Health, National Public Health Institute, HelsinkiMarkus M Nöthen - Department of Medical Genetics Flanders Interuniversity Institute for Biotechnology, Antwerp, BelgiumJohannes Schumacher - Institute of Human Genetics, University of Bonn, Bonn, GermanyChristine Windemuth - Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, GermanyMarcella Rietschel - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, GermanyPeter Propping - Institute of Human Genetics, University of Bonn, Bonn, GermanyWolfgang Maier - Department of Psychiatry, University of Bonn, Bonn, GermanyMartin Alda - Department of Psychiatry, Dalhousie University, Halifax, CanadaPaul Grof - Department of Psychiatry, University of Ottawa, Ottawa, CanadaGuy A Rouleau - Centre for Research in Neuroscience, The Montreal General Hospital Research Institute, McGill University, MontrealJurgen Del-Favero - Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, BelgiumChristine Van Broeckhoven - Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, BelgiumJulien Mendlewicz - Department of Psychiatry, Erasme Hospital, University of Brussels, BrusselsRolf Adolfsson - Department of Clinical Sciences Division of Psychiatry University of Umea, Umea, SwedenM. Anne Spence - Department of Pediatrics, University of California, IrvineHermann Luebbert - Biofrontera Pharmaceuticals, Leverkusen, GermanyLinda J Adams - Garvan Institute of Medical Research, Macquarie University, SydneyJennifer A Donald - School of Biological Science, Macquarie University, SydneyPhilip B Mitchell - School of Psychiatry, University of New South Wales, and Mood Disorders Unit, Prince of Wales Hospital, Macquarie University, SydneyNicholas Barden - Neuroscience Centre Hospitalier de l'Université Laval Research Center and Laval University, QuebecEric Shink - Neuroscience Centre Hospitalier de l'Université Laval Research Center and Laval University, QuebecWilliam Byerley - Department of Psychiatry, University of California, IrvineWalter Muir - Psychiatry and Biological Sciences, University of Edinburgh, EdinburghPeter M Visscher - Psychiatry and Biological Sciences, University of Edinburgh, EdinburghStuart Macgregor - Psychiatry and Biological Sciences, University of Edinburgh, EdinburghHugh Gurling - Molecular Psychiatry Laboratory, Windeyer Institute for Medical Science, Department of Psychiatry and Behavioral Sciences, Royal Free and University College Medical School, University College London, LondonGursharan Kalsi - Molecular Psychiatry Laboratory, Windeyer Institute for Medical Science, Department of Psychiatry and Behavioral Sciences, Royal Free and University College Medical School, University College London, LondonAndrew McQuillin - Molecular Psychiatry Laboratory, Windeyer Institute for Medical Science, Department of Psychiatry and Behavioral Sciences, Royal Free and University College Medical School, University College London, LondonMichael A Escamilla - Department of Psychiatry, University of Texas Health Science Center, San AntonioVictor I Reus - Department of Psychiatry, University of California, San FranciscoPedro Leon - Centro de Biología Molecular y Celular San José, Costa RicaNelson B Freimer - Departments of Psychiatry, University of California, Los AngelesHenrik Ewald - Institute for Basic Psychiatric Research, Aarhus University Hospital, Risskov, DenmarkTorben A Kruse - Department of Clinical Biochemistry and Genetics, Odense University Hospital, Odense, DenmarkOle Mors - Institute for Basic Psychiatric Research, Aarhus University Hospital, Risskov, DenmarkUppala Radhakrishna - Department of Medical Genetics, University of Geneva Medical School and University Hospitals, Geneva, SwitzerlandJean-Louis Blouin - Department of Medical Genetics, University of Geneva Medical School and University Hospitals, Geneva, SwitzerlandStylianos E Antonarakis - Department of Medical Genetics, University of Geneva Medical School and University Hospitals, Geneva, SwitzerlandNurten Akarsu - Department of Pediatrics, Hacettepe University, Ankara, Turkey
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.73(1), pp.49-62
- DOI
- 10.1086/376547
- PMID
- 12802785
- PMCID
- PMC1180589
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2003
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003966402771
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