Journal article
Genome Screen to Detect Linkage to Common Susceptibility Genes for Intracranial and Aortic Aneurysms
Stroke (1970), Vol.40(1), pp.71-76
2009
DOI: 10.1161/STROKEAHA.108.522631
PMCID: PMC2629798
PMID: 18948608
Abstract
Background and purpose: Risk for both intracranial aneurysms (IAs) and aortic aneurysms (AAs) is thought to be heritable with mounting evidence for genetic predisposition. The concept of shared risk for these conditions is challenged by differences in age of diagnosis and demographic characteristics. We performed a genomewide linkage analysis in multiplex families with both IA and AA from the Familial Intracranial Aneurysm study.
Methods: Available medical records of subjects who reported IA or abdominal/thoracic AA were reviewed with adjudication as definite/probable, possible, or not a case. To identify genes contributing to the susceptibility for IA and AA, genomewide linkage analysis was performed in the 26 multiplex IA families who had members who also had thoracic or abdominal AA. Individuals (n=91) were defined as affected if they had an IA (definite/probable) or an aortic or thoracic AA (definite/probable).
Results: Maximum logarithm of odds (LOD) scores were found on chromosomes 11 (144 cM; LOD=3.0) and 6 (33 cM; LOD=2.3). In both chromosomal regions, analyses of these same 26 families considering only IA as the disease phenotype produced LOD scores of 1.8 and 1.6, respectively.
Conclusions: Our linkage analysis in these 26 families using the broadest disease phenotype, including IA, abdominal AA, and thoracic AA, supports the concept of shared genetic risk. The chromosome 11 locus appears to confirm earlier independent associations in IA and AA. The chromosome 6 finding is novel. Both warrant further investigation.
Details
- Title: Subtitle
- Genome Screen to Detect Linkage to Common Susceptibility Genes for Intracranial and Aortic Aneurysms
- Creators
- Bradford B WORRALL - Departments of Neurology and Public Health Sciences University of Virginia, Charlottesville, Va, United StatesTatiana FOROUD - Department of Medical and Molecular Genetics Indiana University School of Medicine, Indianapolis, Ind, United StatesLaura SAUERBECK - Department of Neurology University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesDaniel WOO - Department of Neurology University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesJoseph P BRODERICK - Department of Neurology University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesRobert D BROWN - Department of Neurology, Mayo Clinic, Rochester, Minn, United StatesE. Sander CONNOLLY - Department of Neurological Surgery Columbia University, New York, NY, United StatesRichard W HORNUNG - Departments of Pediatrics and Environmental Health Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United StatesJohn HUSTON - Department of Radiology, Mayo Clinic, Rochester, Minn, United StatesDawn KLEINDORFER - Department of Neurology University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesDaniel L KOLLER - Department of Medical and Molecular Genetics Indiana University School of Medicine, Indianapolis, Ind, United StatesDongbing Lai - Department of Medical and Molecular Genetics Indiana University School of Medicine, Indianapolis, Ind, United StatesCharles J MOOMAW - Department of Neurology University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesFamilial Intracranial Aneurysm Study Investigators
- Contributors
- Colin P Derdeyn (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.40(1), pp.71-76
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1161/STROKEAHA.108.522631
- PMID
- 18948608
- PMCID
- PMC2629798
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 2009
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984013117302771
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