Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study

Camden P Bay; Steven M Levy; Kathleen F Janz; Brian J Smith; John R Shaffer; Mary L Marazita; Trudy L Burns

doi:10.1016/j.jocd.2019.09.005

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Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study

Journal article

Peer reviewed

Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study

Camden P Bay, Steven M Levy, Kathleen F Janz, Brian J Smith, John R Shaffer, Mary L Marazita and Trudy L Burns

Journal of clinical densitometry, Vol.24(1), pp.44-54

01/2021

DOI: 10.1016/j.jocd.2019.09.005

PMCID: PMC7098844

PMID: 31668963

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https://www.ncbi.nlm.nih.gov/pmc/articles/7098844View

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Abstract

The foundation for osteoporosis risk is, in part, established during childhood, adolescence, and young adulthood, all periods of development when bone mass is acquired rapidly. The relative quantity of bone mass accrued is influenced by both lifestyle and genetic factors, although the genetic component is not yet well understood. The purpose of this study was to use a genome-wide association (GWA) analysis to discover single nucleotide polymorphisms (SNPs) associated with: (1) the sex-specific hip bone mineral content at approximately the age of 19 when the amount of bone accrued is near its peak; and (2) the sex-specific rate of hip bone mineral content accrual during the adolescent growth spurt. The Iowa Bone Development Study, a longitudinal cohort study exploring bone health in children, adolescents, and young adults was the source of data. From this cohort, n = 364 (190 females, 174 males) participants were included in GWA analyses to address (1) and n = 258 participants (125 females and 133 males) were included in GWA analyses to address (2). Twenty SNPS were detected having p < 1.0 × 10−5. Of most biologic relevance were 2 suggestive SNPs (rs2051756 and rs2866908) detected in an intron of the DKK2 gene through the GWA analysis that explored peak bone mass in females.

Adolescent bone development

bone mass

DKK2

genome-wide association study

longitudinal

Details

Title: Subtitle: Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study
Creators: Camden P Bay - Center for Clinical Investigation, Brigham & Women's Hospital, Boston, MA, USA
Steven M Levy - Department of Preventive and Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA, USA
Kathleen F Janz - Department of Health and Human Physiology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA, USA
Brian J Smith - Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
John R Shaffer - Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Mary L Marazita - Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Trudy L Burns - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of clinical densitometry, Vol.24(1), pp.44-54
DOI: 10.1016/j.jocd.2019.09.005
PMID: 31668963
PMCID: PMC7098844
NLM abbreviation: J Clin Densitom
ISSN: 1094-6950
eISSN: 1559-0747
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 01/2021
Academic Unit: Preventive and Community Dentistry; Health Management and Policy; Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Holden Comprehensive Cancer Center; Health, Sport, and Human Physiology
Record Identifier: 9984214849002771

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