Genome-Wide Association Study (GWAS) of dental caries in diverse populations

Rasha N Alotaibi; Brian J Howe; Jonathan M Chernus; Nandita Mukhopadhyay; Carla Sanchez; Frederic W B Deleyiannis; Katherine Neiswanger; Carmencita Padilla; Fernando A Poletta; Ieda M Orioli; Carmen J Buxó; Jacqueline T Hecht; George L Wehby; Ross E Long; Alexandre R Vieira; Seth M Weinberg; John R Shaffer; Lina M Moreno Uribe; Mary L Marazita

doi:10.1186/s12903-021-01670-5

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Genome-Wide Association Study (GWAS) of dental caries in diverse populations

Journal article

Open access

Peer reviewed

Genome-Wide Association Study (GWAS) of dental caries in diverse populations

Rasha N Alotaibi, Brian J Howe, Jonathan M Chernus, Nandita Mukhopadhyay, Carla Sanchez, Frederic W B Deleyiannis, Katherine Neiswanger, Carmencita Padilla, Fernando A Poletta, Ieda M Orioli, …

BMC oral health, Vol.21(1), pp.377-377

07/26/2021

DOI: 10.1186/s12903-021-01670-5

PMCID: PMC8311973

PMID: 34311721

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Abstract

Dental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes that contribute to dental caries in specific ethnic groups, usually of European descent. The aim of this study is to conduct a genome-wide association study (GWAS) to identify associations affecting susceptibility to caries in a large multiethnic population from Argentina, the Philippines, Guatemala, Hungary, and the USA, originally recruited for studies of orofacial clefts (POFC, N = 3686). Ages of the participants ranged from 2 to 12 years for analysis of the primary dentition, and 18-60 years for analysis of the permanent dentition. For each participant, dental caries was assessed by counts of decayed and filled teeth (dft/DFT) and genetic variants (single nucleotide polymorphisms, SNPs) were genotyped or imputed across the entire genome. Caries was analyzed separately for the primary and permanent dentitions, with age, gender, and presence/absence of any type of OFC treated as covariates. Efficient Mixed-Model Association eXpedited (EMMAX) was used to test genetic association, while simultaneously accounting for relatedness and stratification. We identified several suggestive loci (5 × 10 < P < 5 × 10 ) within or near genes with plausible biological roles for dental caries, including a cluster of taste receptor genes (TAS2R38, TAS2R3, TAS2R4, TASR25) on chromosome 7 for the permanent dentition analysis, and DLX3 and DLX4 on chromosome 17 for the primary dentition analysis. Genome-wide significant results were seen with SNPs in the primary dentition only; however, none of the identified genes near these variants have known roles in cariogenesis. The results of this study warrant further investigation and may lead to a better understanding of cariogenesis in diverse populations, and help to improve dental caries prediction, prevention, and/or treatment in future.

Adolescent

Adult

Child

Child, Preschool

Cleft Lip

Cleft Palate

Dental Caries - epidemiology

Dental Caries - genetics

DMF Index

Female

Genome-Wide Association Study

Homeodomain Proteins

Humans

Male

Middle Aged

Philippines

Transcription Factors

Young Adult

Details

Title: Subtitle: Genome-Wide Association Study (GWAS) of dental caries in diverse populations
Creators: Rasha N Alotaibi - King Saud University
Brian J Howe - University of Iowa
Jonathan M Chernus - University of Pittsburgh
Nandita Mukhopadhyay - University of Pittsburgh
Carla Sanchez - University of Pittsburgh
Frederic W B Deleyiannis - UC Health Medical Group, Colorado Springs, Denver, USA
Katherine Neiswanger - University of Pittsburgh
Carmencita Padilla - University of the Philippines Manila
Fernando A Poletta - Consejo Nacional de Investigaciones Científicas y Técnicas
Ieda M Orioli - Universidade Federal do Rio de Janeiro
Carmen J Buxó - University of Puerto Rico System
Jacqueline T Hecht - The University of Texas Health Science Center at Houston
George L Wehby - University of Iowa
Ross E Long - Clinic for Special Children
Alexandre R Vieira - University of Pittsburgh
Seth M Weinberg - University of Pittsburgh
John R Shaffer - University of Pittsburgh
Lina M Moreno Uribe - University of Iowa
Mary L Marazita - University of Pittsburgh
Resource Type: Journal article
Publication Details: BMC oral health, Vol.21(1), pp.377-377
DOI: 10.1186/s12903-021-01670-5
PMID: 34311721
PMCID: PMC8311973
NLM abbreviation: BMC Oral Health
ISSN: 1472-6831
eISSN: 1472-6831
Grant note: S21 MD001830 / NIMHD NIH HHS U54 GM133807 / NIGMS NIH HHS R01 DE016148 / NIDCR NIH HHS R01 DE012242 / NIDCR NIH HHS R21 DE016930 / NIDCR NIH HHS R01 DD000295 / NCBDD CDC HHS U54 MD007587 / NIMHD NIH HHS R56 DE027055 / NIDCR NIH HHS R00 DE024571 / NIDCR NIH HHS HHSN268201200008I / NHLBI NIH HHS R37 DE008559 / NIDCR NIH HHS U01 DE024425 / NIDCR NIH HHS R01 DE011931 / NIDCR NIH HHS
Language: English
Date published: 07/26/2021
Academic Unit: Preventive and Community Dentistry; Orthodontics; Health Management and Policy; Economics; Dental Clinic Administration; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Family Dentistry
Record Identifier: 9984367656202771

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