Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders

The NORDiC study was funded by grants from the Swedish Research Council (2015-02271, 2018-02487, and 2020-01343) , Center for Innovative Medicine (Grant No. FoUI-954440) , and the National Institute of Mental Health (Grant No. R01MH110427) . The BIP TIC trial was funded by the Swedish Research Council for Health, Working Life and Welfare (Forte; Grant No. 2017-01066) , Region Stockholm (Grant No. 20180093) , and the Swedish Research Council (Grant No. 2018-00344) . The iPSYCH team was supported by grants from the Lundbeck Foun-dation (Grant Nos. R102-A9118, R155-2014-1724, and R248-2017-2003) , National Institutes of Health/National Institute of Mental Health (Grant Nos. 1U01MH109514-01 and 1R01MH124851-01 [to ADB] ) , and the Universities and University Hospitals of Aarhus and Copenhagen. The Danish National Biobank resource was supported by the Novo Nordisk Foundation. High-performance computer capacity for handling and statistical analysis of iPSYCH data on the GenomeDK high-performance computing facility was provided by the Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing, iSEQ, Aarhus University, Denmark (to ADB) . ADB was also supported by the "European Union's HORIZON-HLTH-2021-STAYHLTH-01 program" (Project No. 10105738566: Risk and Resil-ience in Developmental Diversity and Mental Health [R2D2-MH] ) . We acknowledge the essential contribution of each participant in the studies included in this work. We thank the research participants and em-ployees of 23andMe for making this work possible. The meta-analyzed summary statistics (excl. 23andMe) are available via the Psychiatric Genomics Consortium download page (https:// www.med. unc.edu/pgc/download-results/) . The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. Datasets will be made available at no cost for academic use. For more information and to apply to access the data, see https://research.23andme.com /collaborate/#dataset-access/. DM-C receives royalties from UpToDate, Inc. and is part owner of Scandinavian E -Health AB, all outside the current work. CT, DH, and members of the 23andMe Research Team are employed by and hold stock or stock options in 23andMe, Inc. All other authors report no biomedical financial interests or potential conflicts of interest.