Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients

Roy H Perlis; Jie Huang; Shaun Purcell; Maurizio Fava; A. John Rush; Patrick F Sullivan; Steven P Hamilton; Francis J McMahon; Thomas Schulze; James B Potash; Peter P Zandi; Virginia L Willour; Brenda W Penninx; Dorret I Boomsma; Nicole Vogelzangs; Christel M Middeldorp; Marcella Rietschel; Markus Nöthen; Sven Cichon; Hugh Gurling; Nick Bass; Andrew McQuillin; Marian Hamshere; Nick Craddock; Pamela Sklar; Jordan W Smoller; Wellcome Trust Case Control Consor

doi:10.1176/appi.ajp.2010.10040541

Back

Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients

Journal article

Open access

Peer reviewed

Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients

Roy H Perlis, Jie Huang, Shaun Purcell, Maurizio Fava, A. John Rush, Patrick F Sullivan, Steven P Hamilton, Francis J McMahon, Thomas Schulze, James B Potash, …

American Journal of Psychiatry, Vol.167(12), pp.1499-1507

12/2010

DOI: 10.1176/appi.ajp.2010.10040541

PMCID: PMC3795390

PMID: 21041247

Files and links (1)

url

https://doi.org/10.1176/appi.ajp.2010.10040541View

Published (Version of record) Open Access

Abstract

Objective:Family and twin studies suggest that liability for suicide attempts is heritable and distinct from mood disorder susceptibility. The authors therefore examined the association between common genomewide variation and lifetime suicide attempts. Method:The authors analyzed data on lifetime suicide attempts from genomewide association studies of bipolar I and II disorder as well as major depressive disorder. Bipolar disorder subjects were drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder cohort, the Wellcome Trust Case Control Consortium bipolar cohort, and the University College London cohort. Replication was pursued in the NIMH Genetic Association Information Network bipolar disorder project and a German clinical cohort. Depression subjects were drawn from the Sequential Treatment Alternatives to Relieve Depression cohort, with replication in the Netherlands Study of Depression and Anxiety/Netherlands Twin Register depression cohort. Results:Strongest evidence of association for suicide attempt in bipolar disorder was observed in a region without identified genes (rs1466846); five loci also showed suggestive evidence of association. In major depression, strongest evidence of association was observed for a single nucleotide polymorphism in ABI3BP, with six loci also showing suggestive association. Replication cohorts did not provide further support for these loci. However, meta-analysis incorporating approximately 8,700 mood disorder subjects identified four additional regions that met the threshold for suggestive association, including the locus containing the gene coding for protein kinase C-epsilon, previously implicated in models of mood and anxiety. Conclusions:The results suggest that inherited risk for suicide among mood disorder patients is unlikely to be the result of individual common variants of large effect. They nonetheless provide suggestive evidence for multiple loci, which merit further investigation.

Details

Title: Subtitle: Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients
Creators: Roy H Perlis - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Jie Huang - Massachusetts General Hospital
Shaun Purcell - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Maurizio Fava - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
A. John Rush - National University of Singapore
Patrick F Sullivan - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Steven P Hamilton - University of North Carolina at Chapel Hill
Francis J McMahon - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Thomas Schulze - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
James B Potash - University of Iowa, Psychiatry
Peter P Zandi - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Virginia L Willour - University of Iowa, Iowa Neuroscience Institute
Brenda W Penninx - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Dorret I Boomsma - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Nicole Vogelzangs - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Christel M Middeldorp - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Marcella Rietschel - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Markus Nöthen - University of Bonn
Sven Cichon - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Hugh Gurling - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Nick Bass - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Andrew McQuillin - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Marian Hamshere - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Nick Craddock - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Pamela Sklar - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Jordan W Smoller - From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Wellcome Trust Case Control Consor
Resource Type: Journal article
Publication Details: American Journal of Psychiatry, Vol.167(12), pp.1499-1507
DOI: 10.1176/appi.ajp.2010.10040541
PMID: 21041247
PMCID: PMC3795390
NLM abbreviation: Am J Psychiatry
ISSN: 0002-953X
eISSN: 1535-7228
Publisher: American Psychiatric Publishing
Language: English
Date published: 12/2010
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003906802771

Metrics

29 Record Views

116 Times Cited - Web of Science

See more details