Journal article
Genome scan reveals several loci associated with torus palatinus
Orthodontics & craniofacial research, Vol.28(1), pp.159-165
02/2025
DOI: 10.1111/ocr.12857
PMCID: PMC11701952
PMID: 39291419
Abstract
Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.OBJECTIVETorus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.We assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants.MATERIALS AND METHODSWe assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants.Our GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p-values less than 5 × 10-6. Candidate genes at these suggestive loci have been implicated in normal-range craniofacial features, syndromes with facial and oral malformations, and bone density. We did not find evidence that low-frequency coding variants influence TP risk. In addition, we failed to replicate associations identified in prior genetic studies of TP.RESULTSOur GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p-values less than 5 × 10-6. Candidate genes at these suggestive loci have been implicated in normal-range craniofacial features, syndromes with facial and oral malformations, and bone density. We did not find evidence that low-frequency coding variants influence TP risk. In addition, we failed to replicate associations identified in prior genetic studies of TP.These findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.CONCLUSIONThese findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.
Details
- Title: Subtitle
- Genome scan reveals several loci associated with torus palatinus
- Creators
- Myoung Keun LeeAhmed M El SerganiNoah HerrickRebecca M GreenCarmencita PadillaCarmen J BuxóRoss E LongConsuelo Valencia-RamirezClaudia P Restrepo MuñetonLina M Moreno UribeWasiu L AdeyemoAzeez ButaliMary L MarazitaJohn R ShafferSeth M Weinberg
- Resource Type
- Journal article
- Publication Details
- Orthodontics & craniofacial research, Vol.28(1), pp.159-165
- DOI
- 10.1111/ocr.12857
- PMID
- 39291419
- PMCID
- PMC11701952
- NLM abbreviation
- Orthod Craniofac Res
- ISSN
- 1601-6343
- eISSN
- 1601-6343
- Publisher
- WILEY
- Grant note
- National Institute of Dental and Craniofacial Research: R01-DE016148, R01-DE032122, X01-HG011437, R00-DE024571, S21-MD001830, U54-GM133807
National Institute of Dental and Craniofacial Research, Grant/Award Number: R01-DE016148, R01-DE032122, X01-HG011437, R00-DE024571, S21-MD001830 and U54-GM133807
- Language
- English
- Electronic publication date
- 09/18/2024
- Date published
- 02/2025
- Academic Unit
- Orthodontics; Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984704833302771
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