Genome-wide Association Study of Parental Life Span

Toshiko Tanaka; Ambarish Dutta; Luke C Pilling; Luting Xue; Kathryn L Lunetta; Joanne M Murabito; Stefania Bandinelli; Robert Wallace; David Melzer; Luigi Ferrucci

doi:10.1093/gerona/glw206

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Genome-wide Association Study of Parental Life Span

Journal article

Open access

Peer reviewed

Genome-wide Association Study of Parental Life Span

Toshiko Tanaka, Ambarish Dutta, Luke C Pilling, Luting Xue, Kathryn L Lunetta, Joanne M Murabito, Stefania Bandinelli, Robert Wallace, David Melzer and Luigi Ferrucci

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(10), pp.1407-1410

10/01/2017

DOI: 10.1093/gerona/glw206

PMCID: PMC5861941

PMID: 27816938

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Abstract

Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity. A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted. A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE, MINIPP1, FOXO3, EBF1, CAMKIV, and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002). A promising genetic signal for parental life span was identified but was not replicated in independent samples.

Aged

Aged, 80 and over

Chromosomes, Human, Pair 18

Female

Genome-Wide Association Study

Humans

Longevity - genetics

Male

Middle Aged

Parents

Phenotype

Polymorphism, Single Nucleotide

Trans-Activators - genetics

Details

Title: Subtitle: Genome-wide Association Study of Parental Life Span
Creators: Toshiko Tanaka - National Institute on Aging
Ambarish Dutta - Public Health Foundation of India
Luke C Pilling - University of Exeter
Luting Xue - Boston University
Kathryn L Lunetta - Framingham Heart Study
Joanne M Murabito - Boston University
Stefania Bandinelli - Azienda Sanitaria di Firenze
Robert Wallace - University of Iowa
David Melzer - University of Exeter
Luigi Ferrucci - National Institute on Aging
Resource Type: Journal article
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(10), pp.1407-1410
DOI: 10.1093/gerona/glw206
PMID: 27816938
PMCID: PMC5861941
NLM abbreviation: J Gerontol A Biol Sci Med Sci
ISSN: 1079-5006
eISSN: 1758-535X
Grant note: P30 CA086862 / NCI NIH HHS U01 AG009740 / NIA NIH HHS
Language: English
Date published: 10/01/2017
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364403502771

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