Journal article
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Nature genetics, Vol.51(2), pp.245-257
02/01/2019
DOI: 10.1038/s41588-018-0309-3
PMCID: PMC6713272
PMID: 30643258
Abstract
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
Details
- Title: Subtitle
- Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
- Creators
- Richard Karlsson Linnér - University of AmsterdamPietro Biroli - University of ZurichEdward Kong - Harvard UniversityS Fleur W Meddens - Erasmus University RotterdamRobbee Wedow - Broad InstituteMark Alan Fontana - Hospital for Special SurgeryMaël Lebreton - University of AmsterdamStephen P Tino - University of TorontoAbdel Abdellaoui - Vrije Universiteit AmsterdamAnke R Hammerschlag - Amsterdam NeuroscienceMichel G Nivard - Vrije Universiteit AmsterdamAysu Okbay - Vrije Universiteit AmsterdamCornelius A Rietveld - Erasmus MCPascal N Timshel - University of CopenhagenMaciej Trzaskowski - The University of QueenslandRonald de Vlaming - University of AmsterdamChristian L Zünd - University of ZurichYanchun Bao - Institute for Social and Economic ResearchLaura Buzdugan - ETH ZurichAnn H Caplin - Stuyvesant High School, New York, NY, USAChia-Yen Chen - Massachusetts General HospitalPeter Eibich - Max Planck Institute for Demographic ResearchPierre Fontanillas - 23andMe (United States)Juan R Gonzalez - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaPeter K Joshi - University of EdinburghVille Karhunen - University of OuluAaron Kleinman - 23andMe (United States)Remy Z Levin - University of California San DiegoChristina M Lill - University of LübeckGerardus A MeddensGerard Muntané - Centro de Investigación Biomédica en Red de Salud MentalSandra Sanchez-Roige - University of California San DiegoFrank J van Rooij - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsErdogan Taskesen - Amsterdam NeuroscienceYang Wu - The University of QueenslandFutao Zhang - The University of QueenslandAdam Auton - 23andMe (United States)Jason D Boardman - University of Colorado BoulderDavid W Clark - University of EdinburghAndrew Conlin - University of OuluConor C Dolan - Vrije Universiteit AmsterdamUrs Fischbacher - University of KonstanzPatrick J F Groenen - Erasmus University RotterdamKathleen Mullan Harris - University of North Carolina at Chapel HillGregor Hasler - University of FribourgAlbert Hofman - Erasmus MCMohammad A Ikram - Erasmus MCSonia Jain - University of California San DiegoRobert Karlsson - Karolinska InstitutetRonald C Kessler - Harvard UniversityMaarten Kooyman - SURFsara (Netherlands)James MacKillop - St. Joseph’s Healthcare HamiltonMinna Männikkö - University of OuluCarlos Morcillo-Suarez - Universitat Pompeu FabraMatthew B McQueen - University of Colorado BoulderKlaus M Schmidt - Ludwig-Maximilians-Universität MünchenMelissa C Smart - Institute for Social and Economic ResearchMatthias Sutter - University of CologneA Roy Thurik - Montpellier Business SchoolAndré G Uitterlinden - Erasmus University RotterdamJon White - University College LondonHarriet de Wit - University of ChicagoJian Yang - The University of QueenslandLars Bertram - Imperial College LondonDorret I Boomsma - Vrije Universiteit AmsterdamTõnu Esko - University of TartuErnst Fehr - University of ZurichDavid A Hinds - 23andMe (United States)Magnus Johannesson - Stockholm School of EconomicsMeena Kumari - Institute for Social and Economic ResearchDavid Laibson - Harvard UniversityPatrik K E Magnusson - Karolinska InstitutetMichelle N Meyer - Geisinger Health SystemArcadi Navarro - Universitat Pompeu FabraAbraham A Palmer - University of California San DiegoTune H Pers - Statens Serum InstitutDanielle Posthuma - Amsterdam NeuroscienceDaniel Schunk - Johannes Gutenberg University MainzMurray B Stein - University of California San DiegoRauli Svento - University of OuluHenning Tiemeier - Erasmus MCPaul R H J Timmers - Centre for Global Health ResearchPatrick Turley - University of Southern CaliforniaRobert J Ursano - Uniformed Services University of the Health SciencesGert G Wagner - Max Planck Institute for Human DevelopmentJames F Wilson - Centre for Global Health ResearchJacob Gratten - Mater ResearchJames J Lee - University of MinnesotaDavid Cesarini - New York UniversityDaniel J Benjamin - University of Southern CaliforniaPhilipp D Koellinger - Vrije Universiteit AmsterdamJonathan P Beauchamp - University of Toronto23and Me Research TeamKevin E Thom (Contributor)Social Science Genetic Association Consortium
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.51(2), pp.245-257
- DOI
- 10.1038/s41588-018-0309-3
- PMID
- 30643258
- PMCID
- PMC6713272
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Grant note
- P2C HD066613 / NICHD NIH HHS MC_UU_00007/10 / Medical Research Council R01 AG015819 / NIA NIH HHS G0100594 / Medical Research Council 10119 / Cancer Research UK R01 AG017917 / NIA NIH HHS BB/F022441/1 / Biotechnology and Biological Sciences Research Council R56 AG042568 / NIA NIH HHS T32 AG000186 / NIA NIH HHS G0600237 / Medical Research Council
- Language
- English
- Date published
- 02/01/2019
- Academic Unit
- Economics
- Record Identifier
- 9984936814902771
Metrics
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