Journal article
Genome-wide association scan for childhood caries implicates novel genes
Journal of dental research, Vol.90(12), pp.1457-1462
12/2011
DOI: 10.1177/0022034511422910
PMCID: PMC3215757
PMID: 21940522
Abstract
Dental caries is the most common chronic disease in children and a major public health concern due to its increasing incidence, serious health and social co-morbidities, and socio-demographic disparities in disease burden. We performed the first genome-wide association scan for dental caries to identify associated genetic loci and nominate candidate genes affecting tooth decay in 1305 US children ages 3-12 yrs. Affection status was defined as 1 or more primary teeth with evidence of decay based on intra-oral examination. No associations met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association. Analyses stratified by home fluoride level yielded additional suggestive loci, including TFIP11 in the low-fluoride group, and EPHA7 and ZMPSTE24 in the sufficient-fluoride group. Suggestive loci were tested but not significantly replicated in an independent sample (N = 1695, ages 2-7 yrs) after adjustment for multiple comparisons. This study reinforces the complexity of dental caries, suggesting that numerous loci, mostly having small effects, are involved in cariogenesis. Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries.
Details
- Title: Subtitle
- Genome-wide association scan for childhood caries implicates novel genes
- Creators
- J R Shaffer - Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USAE FeingoldX WangM LeeF BegumD E WeeksK T CuencoM M BarmadaS K WendellD R CrosslinC C LaurieK F DohenyE W PughQ ZhangB FeenstraF GellerH A BoydH ZhangM MelbyeJ C MurrayR J WeyantR CroutD W McNeilS M LevyR L SlaytonM C WillingB BroffittA R VieiraM L Marazita
- Resource Type
- Journal article
- Publication Details
- Journal of dental research, Vol.90(12), pp.1457-1462
- DOI
- 10.1177/0022034511422910
- PMID
- 21940522
- PMCID
- PMC3215757
- NLM abbreviation
- J Dent Res
- ISSN
- 0022-0345
- eISSN
- 1544-0591
- Publisher
- United States
- Grant note
- R01 DE014899 / NIDCR NIH HHS R03-DE021425 / NIDCR NIH HHS U01 DE018903 / NIDCR NIH HHS U01-DE018903 / NIDCR NIH HHS U01-HG004438 / NHGRI NIH HHS U01-HG004446 / NHGRI NIH HHS R01-DE014899 / NIDCR NIH HHS R01 DE009551 / NIDCR NIH HHS R01-DE12101 / NIDCR NIH HHS R01-DE0 9551 / NIDCR NIH HHS U01 HG004446 / NHGRI NIH HHS R01 DE012101 / NIDCR NIH HHS U01 HG004423 / NHGRI NIH HHS UL1 TR000005 / NCATS NIH HHS U01 HG004438 / NHGRI NIH HHS P60-DE-13076 / NIDCR NIH HHS P60 DE013076 / NIDCR NIH HHS R03 DE021425 / NIDCR NIH HHS U01-HG004423 / NHGRI NIH HHS HHSN268200782096C / NHLBI NIH HHS
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Preventive and Community Dentistry; Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9983917683002771
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