Journal article
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
Nature Genetics, Vol.48(5), pp.556-562
05/2016
DOI: 10.1038/ng.3540
PMID: 27064256
Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.
Details
- Title: Subtitle
- Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
- Creators
- Chiea Chuen Khor - Genome Institute of SingaporeTan Do - Vietnam National Institute of OphthalmologyHongyan Jia - Beijing Tongren HospitalMasakazu Nakano - Kyoto University [Kyoto]Ronnie GeorgeKhaled Abu-AmeroRoopam DuveshLi Jia ChenZheng LiMonisha E NongpiurShamira A PereraChunyan QiaoHon-Tym WongHiroshi SakaiMônica Barbosa de MeloMei-Chin LeeAnita S ChanYaakub AzhanyThi Lam Huong DaoYoko IkedaRodolfo A Perez-GrossmannTomasz ZarnowskiAlexander C DayJost B JonasPancy O S TamTuan Anh TranHumaira AyubFarah AkhtarShazia MichealPaul T K ChewLeyla A AljasimTanuj DadaTam Thi LuuMona S AwadallaNaris KitnarongBoonsong WanichwecharungruangYee Yee AungJelinar Mohamed-NoorSaravanan VijayanSripriya SarangapaniRahat HusainAliza JapMani BaskaranDavid GohDaniel H SuHuaizhou WangVernon K YongLeonard W YipTuyet Bach TrinhManchima MakornwattanaEdgar U LeuenbergerKi-Ho ParkWidya Artini WiyogoRajesh S KumarCelso TelloYasuo KurimotoSuman S ThapaKessara PathanapitoonJohn F SalmonYong Ho SohnAntonio FeaMineo OzakiJimmy S M LaiVisanee TantiseviChaw Chaw KhaingTakanori MizoguchiSatoko NakanoChan-Yun KimGuangxian TangSujie FanRenyi WuHailin MengThi Thuy Giang NguyenTien Dat TranMorio UenoJose Maria MartinezNorlina RamliYin Mon AungRigo Daniel ReyesStephen A VernonSeng Kheong FangZhicheng XieXiao Yin Chen - Genome Institute of SingaporeJia Nee FooKar Seng SimDesmond T QuekSrinivasan KavithaSubbiah R KrishnadasNagaswamy SoumittraBalekudaru ShanthaBoon-Ang Lim - Tan Tock Seng HospitalJeanne OgleJosé P C de VasconcellosVital P CostaRicardo Y AbeBruno B de SouzaRengaraj VenkateshThanh Thu NguyenTina T Wong - National University of SingaporeChelvin C Sng
- Contributors
- Fanny SEBIRE (Editor)John H Fingert (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
- Resource Type
- Journal article
- Publication Details
- Nature Genetics, Vol.48(5), pp.556-562
- DOI
- 10.1038/ng.3540
- PMID
- 27064256
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Publisher
- Nature Publishing Group
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980058802771
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