Journal article
Genome-wide association study of conduct disorder symptomatology
Molecular psychiatry, Vol.16(8), pp.800-808
08/2011
DOI: 10.1038/mp.2010.73
PMCID: PMC3580835
PMID: 20585324
Abstract
Conduct disorder (CD) is one of the most prevalent childhood psychiatric conditions, and is associated with a number of serious concomitant and future problems. CD symptomatology is known to have a considerable genetic component, with heritability estimates in the range of 50%. Despite this, there is a relative paucity of studies aimed at identifying genes involved in the susceptibility to CD. In this study, we report results from a genome-wide association study of CD symptoms. CD symptoms were retrospectively reported by a psychiatric interview among a sample of cases and controls, in which cases met the criteria for alcohol dependence. Our primary phenotype was the natural log transformation of the number of CD symptoms that were endorsed, with data available for 3963 individuals who were genotyped on the Illumina Human 1M beadchip array. Secondary analyses are presented for case versus control status, in which caseness was established as endorsing three or more CD symptoms (
N
= 872 with CD and
N
= 3091 without CD). We find four markers that meet the criteria for genome-wide significance (
P
< 5 × 10
−8
) with the CD symptom count, two of which are located in the gene
C1QTNF7
(C1q and tumor necrosis factor-related protein 7). There were six additional SNPs in the gene that yielded converging evidence of association. These data provide the first evidence of a specific gene that is associated with CD symptomatology. None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder.
Details
- Title: Subtitle
- Genome-wide association study of conduct disorder symptomatology
- Creators
- D M Dick - University of Iowa College of Medicine, Iowa City, IA, USAF Aliev - University of Iowa College of Medicine, Iowa City, IA, USAR F Krueger - University of Iowa College of Medicine, Iowa City, IA, USAA Edwards - University of Iowa College of Medicine, Iowa City, IA, USAA Agrawal - University of Iowa College of Medicine, Iowa City, IA, USAM Lynskey - University of Iowa College of Medicine, Iowa City, IA, USAP Lin - University of Iowa College of Medicine, Iowa City, IA, USAM Schuckit - University of Iowa College of Medicine, Iowa City, IA, USAV Hesselbrock - University of Iowa College of Medicine, Iowa City, IA, USAJ Nurnberger - University of Iowa College of Medicine, Iowa City, IA, USAL Almasy - University of Iowa College of Medicine, Iowa City, IA, USAB Porjesz - University of Iowa College of Medicine, Iowa City, IA, USAH J Edenberg - University of Iowa College of Medicine, Iowa City, IA, USAK Bucholz - University of Iowa College of Medicine, Iowa City, IA, USAJ Kramer - University of Iowa College of Medicine, Iowa City, IA, USAS Kuperman - University of Iowa College of Medicine, Iowa City, IA, USAL Bierut - University of Iowa College of Medicine, Iowa City, IA, USASAGE & GEBEVA Consortia
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.16(8), pp.800-808
- DOI
- 10.1038/mp.2010.73
- PMID
- 20585324
- PMCID
- PMC3580835
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Grant note
- R01 DA013423-05 || DA / National Institute on Drug Abuse : NIDA P01 CA089392-08 || CA / National Cancer Institute : NCI U01 HG004422-02 || HG / National Human Genome Research Institute : NHGRI U01 HG004422 || HG / National Human Genome Research Institute : NHGRI R01 DA013423 || DA / National Institute on Drug Abuse : NIDA R01 DA019963-03 || DA / National Institute on Drug Abuse : NIDA R01 DA019963-02 || DA / National Institute on Drug Abuse : NIDA R01 DA025888-01A1 || DA / National Institute on Drug Abuse : NIDA R01 DA025888 || DA / National Institute on Drug Abuse : NIDA U10 AA008401 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA R01 DA019963 || DA / National Institute on Drug Abuse : NIDA
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003920502771
Metrics
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