Journal article
Genome-wide association study of event-free survival in follicular lymphoma patients treated with front-line immunochemotherapy
Blood cancer journal (New York)
01/09/2026
DOI: 10.1038/s41408-025-01435-1
PMID: 41513626
Abstract
Genome-wide association studies (GWAS) have identified germline genetic variants for follicular lymphoma (FL) susceptibility. We conducted a GWAS of prognosis in FL patients to identify genetic predictors of event-free survival (EFS) as well as failure within the first 24 months after treatment initiation (EFS24) using patients treated with rituximab-based immunochemotherapy from three clinical trials and one prospective observational study (N = 1054). Statistical approaches consisted of a pooled GWAS of the four cohorts and a leave-one-cohort-out (LOCO) strategy to identify robust findings that replicated across the four cohorts. The top SNPs for EFS and EFS24 were marked by rs72625024 at 3q27.3 near FETUB and HRG (P = 9.37 × 10
) and rs114695031 at 14q32.13 near TCL6 (P = 1.93 × 10
), respectively. These two loci, which were discovered and validated in all 4 LOCO rounds, map near long-non-coding RNAs with putative tumor suppressor functions. Our results pinpoint potential novel biology and the contribution of host genetics to prognosis in FL.
Details
- Title: Subtitle
- Genome-wide association study of event-free survival in follicular lymphoma patients treated with front-line immunochemotherapy
- Creators
- Hervé Ghesquières - Université Claude Bernard Lyon 1Youenn Drouet - Centre Léon BérardSusan L Slager - Mayo ClinicFranck Morschhauser - Centre Hospitalier Universitaire de LilleEdith Julia - Hospices Civils de LyonSara Galimberti - University of PisaDennis Robinson - Mayo ClinicMelissa C Larson - Mayo ClinicQuentin Testard - HCL TechnologiesBruno Tesson - Lymphoma Study AssociationJean-François Deleuze - Centre National de Recherche en Génomique HumaineAnne Boland - Centre National de Recherche en Génomique HumaineEmilie Thomas - Centre de Recherche en Cancérologie de LyonChristine Lasset - Université Claude Bernard Lyon 1Anne J Novak - Mayo ClinicLuc Xerri - Institut Paoli-CalmettesStefano Luminari - Azienda Sanitaria Unità Locale di Reggio EmiliaAurelie Verney - Centre National de la Recherche ScientifiqueCamille Laurent - Centre de Recherche en Cancérologie de ToulouseLisa M Rimsza - Mayo Clinic in ArizonaThomas M Habermann - Mayo Clinic in ArizonaMassimo Federico - University of Modena and Reggio EmiliaBrian K Link - University of IowaGilles Salles - Memorial Sloan Kettering Cancer CenterJames R Cerhan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Blood cancer journal (New York)
- DOI
- 10.1038/s41408-025-01435-1
- PMID
- 41513626
- NLM abbreviation
- Blood Cancer J
- ISSN
- 2044-5385
- eISSN
- 2044-5385
- Publisher
- Springer Nature
- Grant note
- P30 CA008748 / NCI NIH HHS P50 CA97274, U01 CA195568 / U.S. Department of Health & Human Services | National Institutes of Health (NIH)
- Language
- English
- Electronic publication date
- 01/09/2026
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9985116068502771
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