Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

M. G MCINNIS; T-H LAN; Y HUO; T SWIFT-SCANLAN; H CHEN; R KOSKELA; Colin STINE; K. R JAMISON; P HOLMANS; S. E FOLSTEIN; K RANADE; C FRIDDLE; V. L WILLOUR; D BOTSTEIN; T MARR; T. H BEATY; P ZANDI; J. Raymond DEPAULO; F. J MCMAHON; S. G SIMPSON; A. M ADDINGTON; D. F MACKINNON; J. B POTASH; A. T MAHONEY; J CHELLIS

doi:10.1038/sj.mp.4001277

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Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

Journal article

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Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

M. G MCINNIS, T-H LAN, Y HUO, T SWIFT-SCANLAN, H CHEN, R KOSKELA, Colin STINE, K. R JAMISON, P HOLMANS, S. E FOLSTEIN, …

Molecular psychiatry, Vol.8(3), pp.288-298

2003

DOI: 10.1038/sj.mp.4001277

PMID: 12660801

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Abstract

The purpose of this study was to assess 65 pedigrees ascertained through a Bipolar I (BPI) proband for evidence of linkage, using nonparametric methods in a genome-wide scan and for possible parent of origin effect using several analytical methods. We identified 15 loci with nominally significant evidence for increased allele sharing among affected relative pairs. Eight of these regions, at 8q24, 18q22, 4q32, 13q12, 4q35, 10q26, 2p12, and 12q24, directly overlap with previously reported evidence of linkage to bipolar disorder. Five regions at 20p13, 2p22, 14q23, 9p13, and 1q41 are within several Mb of previously reported regions. We report our findings in rank order and the top five markers had an NPL>2.5. The peak finding in these regions were D8S256 at 8q24, NPL 3.13; D18S878 at 18q22, NPL 2.90; D4S1629 at 4q32, NPL 2.80; D2S99 at 2p12, NPL 2.54; and D13S1493 at 13q12, NPL 2.53. No locus produced statistically significant evidence for linkage at the genome-wide level. The parent of origin effect was studied and consistent with our previous findings, evidence for a locus on 18q22 was predominantly from families wherein the father or paternal lineage was affected. There was evidence consistent with paternal imprinting at the loci on 13q12 and 1q41.

Psychology. Psychoanalysis. Psychiatry

Adult and adolescent clinical studies

Psychopathology. Psychiatry

Mood disorders

Biological and medical sciences

Medical sciences

Bipolar disorders

Details

Title: Subtitle: Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12
Creators: M. G MCINNIS - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
T-H LAN - Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States
Y HUO - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
T SWIFT-SCANLAN - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
H CHEN - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
R KOSKELA - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
Colin STINE - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
K. R JAMISON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
P HOLMANS - MRC Biostatistics Unit, Cambridge, United Kingdom
S. E FOLSTEIN - Department of Psychiatry, Tufts University, Boston, MA, United States
K RANADE - Department of Genetics, Stanford University, Palo Alto, CA, United States
C FRIDDLE - Department of Genetics, Stanford University, Palo Alto, CA, United States
V. L WILLOUR - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
D BOTSTEIN - Department of Psychiatry, Tufts University, Boston, MA, United States
T MARR - CNS Genetics Corp, Saginaw, MI 48603, United States
T. H BEATY - Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States
P ZANDI - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
J. Raymond DEPAULO - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
F. J MCMAHON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
S. G SIMPSON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
A. M ADDINGTON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
D. F MACKINNON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
J. B POTASH - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
A. T MAHONEY - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
J CHELLIS - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
Resource Type: Journal article
Publication Details: Molecular psychiatry, Vol.8(3), pp.288-298
Publisher: Nature Publishing Group; Basingstoke
DOI: 10.1038/sj.mp.4001277
PMID: 12660801
ISSN: 1359-4184
eISSN: 1476-5578
Language: English
Date published: 2003
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984070639302771

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