Journal article
Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast
FEBS letters, Vol.515(1), pp.25-28
2002
DOI: 10.1016/S0014-5793(02)02387-6
PMID: 11943188
Abstract
Gain-of-function mutations in the transcription factors Pdr1p and Pdr3p lead to the up-regulation of genes controlling plasma membrane properties. Pdr3p is involved in a retrograde response in which mitochondrial dysfunctions activate
PDR5, a gene encoding an ABC membrane transporter. We carried out genome-wide analyses of the
PDR3-controlled genes activated by the deletion of the mitochondrial DNA. We present evidence showing that
PDR1 does not interfere with this
PDR3 response. We also showed that the mitochondrially activated
PDR3 response is highly sensitive to both yeast strain variations and carbon sources. These observations explain the apparent discrepancies in published studies and better describe the connections between the mitochondrial state and plasma membrane properties.
Details
- Title: Subtitle
- Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast
- Creators
- Frédéric Devaux - Laboratoire de Génétique Moléculaire, CNRS,
UMR 8541, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris Cedex 05, France.Elvira Carvajal - Rio de Janeiro State UniversityScott Moye-Rowley - University of IowaClaude Jacq - Laboratoire de Génétique Moléculaire, CNRS,
UMR 8541, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris Cedex 05, France. - Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.515(1), pp.25-28
- DOI
- 10.1016/S0014-5793(02)02387-6
- PMID
- 11943188
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2002
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297606002771
Metrics
5 Record Views