Journal article
Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative
American journal of human genetics, Vol.73(1), pp.107-114
2003
DOI: 10.1086/376562
PMCID: PMC1180573
PMID: 12772088
Abstract
We conducted genomewide linkage analyses on 1,152 individuals from 250 families segregating for bipolar disorder and related affective illnesses. These pedigrees were ascertained at 10 sites in the United States, through a proband with bipolar I affective disorder and a sibling with bipolar I or schizoaffective disorder, bipolar type. Uniform methods of ascertainment and assessment were used at all sites. A 9-cM screen was performed by use of 391 markers, with an average heterozygosity of 0.76. Multipoint, nonparametric linkage analyses were conducted in affected relative pairs. Additionally, simulation analyses were performed to determine genomewide significance levels for this study. Three hierarchical models of affection were analyzed. Significant evidence for linkage (genomewide
P<.05) was found on chromosome 17q, with a peak maximum LOD score of 3.63, at the marker D17S928, and on chromosome 6q, with a peak maximum LOD score of 3.61, near the marker D6S1021. These loci met both standard and simulation-based criteria for genomewide significance. Suggestive evidence of linkage was observed in three other regions (genomewide
P<.10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder.
Details
- Title: Subtitle
- Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative
- Creators
- Danielle M Dick - Indiana University, IndianapolisTatiana Foroud - Indiana University, IndianapolisLeah Flury - Indiana University, IndianapolisElizabeth S Bowman - Indiana University, IndianapolisMarvin J Miller - Indiana University, IndianapolisN. Leela Rau - Indiana University, IndianapolisP. Ryan Moe - Indiana University, IndianapolisNalini Samavedy - Indiana University, IndianapolisRif El-Mallakh - University of Louisville, Louisville, KYHusseini Manji - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, U. S. Department of Health and Human Services, BethesdaDebra A Glitz - Wayne State University, DetroitEric T Meyer - Indiana University, IndianapolisCarrie Smiley - Indiana University, IndianapolisRhoda Hahn - University of California Irvine, IrvineClifford Widmark - University of California Irvine, IrvineRebecca McKinney - University of California San Diego, San DiegoLaura Sutton - University of California San Diego, San DiegoChristos Ballas - University of Pennsylvania, PhiladelphiaDorothy Grice - University of Pennsylvania, PhiladelphiaWade Berrettini - University of Pennsylvania, PhiladelphiaWilliam Byerley - University of California Irvine, IrvineWilliam Coryell - University of Iowa, Iowa CityRaymond DePaulo - Johns Hopkins University, BaltimoreDean F MacKinnon - Johns Hopkins University, BaltimoreElliot S Gershon - University of Chicago, ChicagoJohn R Kelsoe - University of California San Diego, San DiegoFrancis J McMahon - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, U. S. Department of Health and Human Services, BethesdaMelvin McInnis - Johns Hopkins University, BaltimoreDennis L Murphy - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, U. S. Department of Health and Human Services, BethesdaTheodore Reich - Washington University, St. LouisWilliam Scheftner - Rush-Presbyterian Medical Center, ChicagoJohn I Nurnberger - Indiana University, Indianapolis
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.73(1), pp.107-114
- Publisher
- Elsevier Inc
- DOI
- 10.1086/376562
- PMID
- 12772088
- PMCID
- PMC1180573
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 2003
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003958802771
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