Journal article
Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a County Jail
Open forum infectious diseases, Vol.11(2), p.ofad675
02/01/2024
DOI: 10.1093/ofid/ofad675
PMCID: PMC10878058
PMID: 38379564
Abstract
Background: In the coronavirus disease 2019 (COVID-19) pandemic, correctional facilities are potential hotspots for transmission. We examined the genomic epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the pandemic in one of the country's largest urban jails. Methods: Existing SARS-CoV-2 isolates from 131 detainees at the Cook County Jail in Chicago, Illinois, from March 2020 through May 2020 were analyzed by whole-genome sequencing. Contemporaneous isolates from Rush University Medical Center (Chicago, Illinois) and the Global Initiative on Sharing All Influenza Data (GISAID) were used to identify genetic clusters containing only jail isolates. Transmission windows were identified for each pair of detainees using the date of the SARS-CoV-2-positive test and location data to determine if detainees overlapped in the jail, within a specific building, or within particular living units during transmission windows. Results: We identified 29 jail-only clusters that contained 75 of the 132 SARS-CoV-2 isolates from detainees; of these clusters, 17 (58.6%) had individuals who overlapped in the jail during putative transmission windows. Focusing on specific buildings revealed that 2 buildings, a single- and double-cell style of housing. were associated with having detainees infected with similar SARS-CoV-2 genomes during their infectious time period (P < .001). Conclusions: Our findings suggest that there was transmission of SARS-CoV-2 in the jail, in the setting of extensive importation of COVID-19 from the community. Numerous infection control practices at intake and during incarceration were implemented in the jail to limit viral spread. Our study shows the importance of genomic analysis in this type of settings and how it can be utilized within infection control protocols.
Details
- Title: Subtitle
- Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a County Jail
- Creators
- Timileyin Adediran - University of MichiganChad Zawitz - Cook County Health and Hospitals SystemAli Piriani - University of MichiganEmily Bendict - University of MichiganStephanie Thiede - University of MichiganHannah Barbian - Rush University Medical CenterAlla Aroutcheva - Cook County Health and Hospitals SystemStefan J. Green - Rush University Medical CenterSharon Welbel - Cook County Health and Hospitals SystemRobert A. Weinstein - Cook County Health and Hospitals SystemEvan Snitkin - University of MichiganKyle J. Popovich - Rush University Medical Center
- Resource Type
- Journal article
- Publication Details
- Open forum infectious diseases, Vol.11(2), p.ofad675
- DOI
- 10.1093/ofid/ofad675
- PMID
- 38379564
- PMCID
- PMC10878058
- NLM abbreviation
- Open Forum Infect Dis
- ISSN
- 2328-8957
- eISSN
- 2328-8957
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Grant note
- R01AI46079-02S1 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 5T32 AG062403-03 / National Institute of Aging (Epidemiology of Aging training)
- Language
- English
- Date published
- 02/01/2024
- Academic Unit
- Epidemiology
- Record Identifier
- 9985123937602771
Metrics
2 Record Views