Genomic Risk Factors for Urethral Stricture: A Systematic Review and Gene Network Analysis

Ilaha Isali; Thomas R Wong; Chen-Han Wilfred Wu; Kyle Scarberry; Shubham Gupta; Bradley A Erickson; Benjamin N Breyer

doi:10.1016/j.urology.2023.12.014

Back

Genomic Risk Factors for Urethral Stricture: A Systematic Review and Gene Network Analysis

Journal article

Peer reviewed

Genomic Risk Factors for Urethral Stricture: A Systematic Review and Gene Network Analysis

Ilaha Isali, Thomas R Wong, Chen-Han Wilfred Wu, Kyle Scarberry, Shubham Gupta, Bradley A Erickson and Benjamin N Breyer

Urology (Ridgewood, N.J.), Vol.184, pp.251-258

02/2024

DOI: 10.1016/j.urology.2023.12.014

PMID: 38160764

Files and links (1)

url

https://escholarship.org/content/qt3182t027/qt3182t027.pdf?t=sj8mntView

Open Access

Abstract

To identify genes that may play a role in urethral stricture and summarize the results of studies that have documented variations in gene expression among individuals with urethral stricture compared to healthy individuals. A systematic search was conducted in Cochrane, Ovid, Web of Science, and PubMed, limiting the results to articles published between January 1, 2000 and January 30, 2023. Only studies comparing the difference in gene expression between individuals with urethral stricture and healthy individuals utilizing molecular techniques to measure gene expression in blood, urine, or tissue samples were included in this systematic review. Gene network and pathway analyses were performed using Cytoscape software, with input data obtained from our systematic review of differentially expressed genes in urethral stricture. Four studies met our criteria for inclusion. The studies used molecular biology methods to quantify gene expression data from specimens. The analysis revealed gene expressions of CXCR3 and NOS2 were downregulated in urethral tissue samples, while TGFB1, UPK3A and CTGF were upregulated in urine samples, plasma and urine samples, and urethral tissue samples, respectively, in patients with urethral stricture compared to healthy controls. The analysis demonstrated that the most significant pathways were associated with phosphoinositide 3-kinase (PI3 kinase) and transforming growth factor beta 1/suppressor of mothers against decapentaplegic (TGF-β1/SMAD) signaling pathways. This systematic review identified gene expression variations in several candidate genes and identified underlying biological pathways associated with urethral stricture. These findings could inform further research and potentially shift treatment and prevention strategies for urethral stricture.

Details

Title: Subtitle: Genomic Risk Factors for Urethral Stricture: A Systematic Review and Gene Network Analysis
Creators: Ilaha Isali - Case Western Reserve University
Thomas R Wong - Case Western Reserve University
Chen-Han Wilfred Wu
Kyle Scarberry - Case Western Reserve University
Shubham Gupta - Case Western Reserve University
Bradley A Erickson - University of Iowa
Benjamin N Breyer - University of California, San Francisco
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.184, pp.251-258
DOI: 10.1016/j.urology.2023.12.014
PMID: 38160764
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Language: English
Electronic publication date: 12/29/2023
Date published: 02/2024
Academic Unit: Urology
Record Identifier: 9984539648702771

Metrics

4 Record Views