Journal article
Genomic analyses in African populations identify novel risk loci for cleft palate
Human molecular genetics, Vol.28(6), pp.1038-1051
03/15/2019
DOI: 10.1093/hmg/ddy402
PMCID: PMC6400042
PMID: 30452639
Abstract
Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several previously reported loci including PAX7 and VAX1.
Details
- Title: Subtitle
- Genomic analyses in African populations identify novel risk loci for cleft palate
- Creators
- Azeez Butali - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAPeter A Mossey - Department of Orthodontics, University of Dundee, Dundee, UKWasiu L Adeyemo - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaMekonen A Eshete - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaLord J J Gowans - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaTamara D Busch - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USADeepti Jain - Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USAWenjie Yu - Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USALiu Huan - State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST, Ministry of Science and Technology) and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, ChinaCecelia A Laurie - University of WashingtonCathy C Laurie - Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USASarah Nelson - Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USAMary Li - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAPedro A Sanchez-Lara - Department of Pediatrics, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USAWilliam P Magee - Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USAKathleen S MageeAllyn Auslander - Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USAFrederick Brindopke - Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USADenise M Kay - Wadsworth Center, New York State Department of Health, Albany, NY, USAMichele Caggana - Wadsworth Center, New York State Department of Health, Albany, NY, USAPaul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa, IA, USAJames L Mills - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, USARosemary Audu - Department of Virology, Nigerian Institute of Medical Research, Yaba, Lagos, NigeriaChika Onwuamah - Department of Virology, Nigerian Institute of Medical Research, Yaba, Lagos, NigeriaGaniyu O Oseni - Department of Plastic Surgery, Ladoke Akintola University of Science and Technology, Osogbo, Oyo, NigeriaArwa Owais - Department of Pediatric Dentistry, University of Iowa, Iowa, IA, USAOlutayo James - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaPeter B Olaitan - Department of Plastic Surgery, Ladoke Akintola University of Science and Technology, Osogbo, Oyo, NigeriaBabatunde S Aregbesola - Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, NigeriaRamat O Braimah - Department of Oral and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, NigeriaFadekemi O Oginni - Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, NigeriaAyodeji O Oladele - Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, NigeriaSaidu A Bello - State House Clinic, Asokoro, Abuja, NigeriaJennifer Rhodes - Virginia Commonwealth University School of Medicine, Richmond, VA, USARita Shiang - Virginia Commonwealth University School of Medicine, Richmond, VA, USAPeter Donkor - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaSolomon Obiri-Yeboah - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaFareed Kow Nanse Arthur - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaPeter Twumasi - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaPius Agbenorku - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaGyikua Plange-Rhule - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaAlexander Acheampong Oti - Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, GhanaOlugbenga M Ogunlewe - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaAfisu A Oladega - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaAdegbayi A Adekunle - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaAkinwunmi O Erinoso - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaOlatunbosun O Adamson - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaAbosede A Elufowoju - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaOluwanifemi I Ayelomi - Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, NigeriaTaiye Hailu - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaAbiye Hailu - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaYohannes Demissie - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaMiliard Derebew - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaSteve Eliason - Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USAMiguel Romero-Bustillous - Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USACynthia Lo - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAJames Park - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAShaan Desai - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAMuiawa Mohammed - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USAFirke Abate - School of Public Health, Addis Ababa University, Addis Ababa, EthiopiaLukman O Abdur-Rahman - Division of Pediatric Surgery, Department of Surgery, University of Ilorin, Ilorin, Kwara, NigeriaDeepti Anand - Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USAIrfaan Saadi - Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas, KS, USAAbimibola V Oladugba - Department of Biostatistics, University of Nigeria, Nssuka, Enugu, NigeriaSalil A Lachke - Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USABrad A Amendt - Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USACharles N Rotimi - Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USAMary L Marazita - Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine; Department of Human Genetics, Graduate School of Public Health, and Clinical and Translational Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USARobert A Cornell - Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa, IA, USAAdebowale A Adeyemo - Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.28(6), pp.1038-1051
- DOI
- 10.1093/hmg/ddy402
- PMID
- 30452639
- PMCID
- PMC6400042
- NLM abbreviation
- Hum Mol Genet
- ISSN
- 1460-2083
- eISSN
- 1460-2083
- Publisher
- England
- Grant note
- R01 DE026172 / NIDCR NIH HHS P30 ES005605 / NIEHS NIH HHS K99 DE022378 / NIDCR NIH HHS HHSN275201100001C / NICHD NIH HHS ZIA HG200362 / Intramural NIH HHS R00 DE022378 / NIDCR NIH HHS R01 DE008559 / NIDCR NIH HHS R01 DE016148 / NIDCR NIH HHS HHSN275201100001G / NICHD NIH HHS R56 DE023575 / NIDCR NIH HHS U01 DD001035 / NCBDD CDC HHS R01 DE023575 / NIDCR NIH HHS R37 DE008559 / NIDCR NIH HHS HHSN275201100001I / NICHD NIH HHS U01 DD001223 / NCBDD CDC HHS
- Language
- English
- Date published
- 03/15/2019
- Academic Unit
- Oral Pathology, Radiology and Medicine; Biostatistics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Orthodontics; Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Public Policy Center (Archive); Dental Research; Internal Medicine
- Record Identifier
- 9983996056802771
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