Journal article
Genomic evidence for population-specific responses to co-evolving parasites in a New Zealand freshwater snail
Molecular ecology, Vol.26(14), pp.3663-3675
07/2017
DOI: 10.1111/mec.14146
PMID: 28429458
Abstract
Reciprocal co-evolving interactions between hosts and parasites are a primary source of strong selection that can promote rapid and often population- or genotype-specific evolutionary change. These host-parasite interactions are also a major source of disease. Despite their importance, very little is known about the genomic basis of co-evolving host-parasite interactions in natural populations, especially in animals. Here, we use gene expression and sequence evolution approaches to take critical steps towards characterizing the genomic basis of interactions between the freshwater snail Potamopyrgus antipodarum and its co-evolving sterilizing trematode parasite, Microphallus sp., a textbook example of natural coevolution. We found that Microphallus-infected P. antipodarum exhibit systematic downregulation of genes relative to uninfected P. antipodarum. The specific genes involved in parasite response differ markedly across lakes, consistent with a scenario where population-level co-evolution is leading to population-specific host-parasite interactions and evolutionary trajectories. We also used an F
-based approach to identify a set of loci that represent promising candidates for targets of parasite-mediated selection across lakes as well as within each lake population. These results constitute the first genomic evidence for population-specific responses to co-evolving infection in the P. antipodarum-Microphallus interaction and provide new insights into the genomic basis of co-evolutionary interactions in nature.
Details
- Title: Subtitle
- Genomic evidence for population-specific responses to co-evolving parasites in a New Zealand freshwater snail
- Creators
- Laura Bankers - Department of Biology, University of Iowa, Iowa City, IA, USAPeter Fields - Zoologisches Institut, Universität Basel, Basel, SwitzerlandKyle E McElroy - Department of Biology, University of Iowa, Iowa City, IA, USAJeffrey L Boore - Department of Integrative Biology, University of California, Berkeley, CA, USAJohn M Logsdon Jr - BiologyMaurine Neiman - Department of Biology, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Molecular ecology, Vol.26(14), pp.3663-3675
- DOI
- 10.1111/mec.14146
- PMID
- 28429458
- NLM abbreviation
- Mol Ecol
- ISSN
- 0962-1083
- eISSN
- 1365-294X
- Grant note
- DOI: 10.13039/100000152, name: Division of Molecular and Cellular Biosciences, award: 1122176; DOI: 10.13039/100000152, name: Division of Molecular and Cellular Biosciences, award: 1122176
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Office Of The Provost; Gender, Women's and Sexuality Studies; Biology
- Record Identifier
- 9984217423902771
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