Journal article
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders
Molecular psychiatry, Vol.28(8), pp.3391-3396
08/2023
DOI: 10.1038/s41380-023-02117-9
PMCID: PMC10618091
PMID: 37344610
Abstract
Recent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations. However, studies have yet to examine the genetics of PTSD while factoring in risk for alcohol dependence, which commonly co-occur. We examined genome-wide associations for DSM-IV PTSD among 4,978 trauma-exposed participants (31% with alcohol dependence, 50% female, 30% African ancestry) from the Collaborative Study on the Genetics of Alcoholism (COGA). We also examined associations of polygenic risk scores (PRS) derived from the Psychiatric Genomics Consortium (PGC)-PTSD Freeze 2 (N = 3533) and Million Veterans Program GWAS of PTSD (N = 5200) with PTSD and substance dependence in COGA, and moderating effects of sex and alcohol dependence. 7.3% of COGA participants met criteria for PTSD, with higher rates in females (10.1%) and those with alcohol dependence (12.3%). No independent loci met genome-wide significance in the PTSD meta-analysis of European (EA) and African ancestry (AA) participants. The PGC-PTSD PRS was associated with increased risk for PTSD (B = 0.126, p < 0.001), alcohol dependence (B = 0.231, p < 0.001), and cocaine dependence (B = 0.086, p < 0.01) in EA individuals. A significant interaction was observed, such that EA individuals with alcohol dependence and higher polygenic risk for PTSD were more likely to have PTSD (B = 0.090, p < 0.01) than those without alcohol dependence. These results further support the importance of examining substance dependence, specifically alcohol dependence, and PTSD together when investigating genetic influence on these disorders.
Details
- Title: Subtitle
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders
- Creators
- Stacey Saenz de ViteriJian ZhangEmma C JohnsonPeter B BarrHoward J EdenbergVictor M HesselbrockJohn I NurnbergerAshwini K PandeyChella KamarajanSivan KinreichJay A TischfieldMartin H PlaweckiJohn R KramerDongbing LaiSamuel KupermanGrace ChanVivia V McCutcheonKathleen K BucholzBernice PorjeszJacquelyn L Meyers
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.28(8), pp.3391-3396
- DOI
- 10.1038/s41380-023-02117-9
- PMID
- 37344610
- PMCID
- PMC10618091
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Grant note
- DOI: 10.13039/100000027, name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism, award: U10AA008401, R01AA030010, U10AA008401, U10AA008401, U10AA008401, U10AA008401, R01AA030010; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism; name: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism
- Language
- English
- Electronic publication date
- 06/21/2023
- Date published
- 08/2023
- Academic Unit
- Psychiatry
- Record Identifier
- 9984436457502771
Metrics
6 Record Views