Journal article
Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest
Archiv fur Geschwulstforschung, Vol.58(2), pp.73-77
1988
PMID: 3288166
Abstract
The most extensively studied model of plasmacytomagenesis is the induction of plasmacytomas in BALB/c mice by i.p. injections of mineral oil or, chemically more defined, by several branched alkanes such as pristane (2.6.10.14-tetramethylpentadecane), phytane (2.6.10.14-tetramethylhexadecane), and 7-n-hexyloctadecane. The available evidence suggests that the primary biologic action of these plasmacytomagenic agents is to induce the formation of a chronic granulomatous tissue, the histological matrix of plasmacytoma development. However, certain genotoxic effects caused by the presence of these substances can not be ruled out a priori. Pristane, 2-methyldodecane, and 1.3-di-tert-butyl-5-methyl-cyclohexane as well as perhydroanthracene and hexahydrodibenzsuberane were proofed as potential genotoxic agents by the SOS chromotest, a quantitative bacterial colorimetric assay for genotoxins. The substances tested did not express any sign of genotoxicity, but exerted toxic effects to the E. coli tester strain.
Details
- Title: Subtitle
- Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest
- Creators
- S Janz - Institute of Clinical Immunology, Karl-Marx-University, Leipzig, G.D.RT HuttunenR HerzschuhH Storch
- Resource Type
- Journal article
- Publication Details
- Archiv fur Geschwulstforschung, Vol.58(2), pp.73-77
- PMID
- 3288166
- ISSN
- 0003-911X
- Language
- English
- Date published
- 1988
- Academic Unit
- Pathology
- Record Identifier
- 9984083839402771
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