Journal article
Genotoxicity assessment of waste products of aluminum plasma etching with the SOS chromotest
Mutation Research/Genetic Toxicology, Vol.300(2), pp.99-109
1993
DOI: 10.1016/0165-1218(93)90127-Y
PMID: 7685499
Abstract
We evaluated 36 characteristic waste products from the plasma etching of aluminum for genotoxicity with the SOS chromotest. The majority of the samples showed genotoxic activity in tester strain
Escherichia coli PQ37 without metabolic activation using S9 mix. In the presence of S9, a deactivation of the samples was regularly observed. Comparable studies with the Salmonella/microsome (Ames) test using tester strains
Salmonella typhimurium TA98 and TA100 indicated actual mutagenicity of waste products.
Gas chromatograms of the organic constituents of all waste products were performed in parallel with the genotoxicity assays. In contrast to the similarity of the peak patterns of all chromatograms, the biological effects of individual waste samples showed large differences. Information on chemical composition and the SOS chromotest results of a representative sample recovered over a period of 2 years is given. For this sample, the influences of sample preparation and cytotoxic matrix effects on the test parameters are also shown.
Details
- Title: Subtitle
- Genotoxicity assessment of waste products of aluminum plasma etching with the SOS chromotest
- Creators
- F Raabe - Institute of Clinical Immunology, Faculty of Medicine University Leipzig, Leipzig, GermanyS Janz - Institute of Clinical Immunology, Faculty of Medicine University Leipzig, Leipzig, GermanyG Wolff - Institute of Clinical Immunology, Faculty of Medicine University Leipzig, Leipzig, GermanyH Merten - Institute Fresenius, Dresden, GermanyA Landrock - Institute Fresenius, Dresden, GermanyT Birkenfeld - Department of Analysis, Faculty of Chemistry, University Leipzig, Leipzig, GermanyR Herzschuh - Department of Analysis, Faculty of Chemistry, University Leipzig, Leipzig, Germany
- Resource Type
- Journal article
- Publication Details
- Mutation Research/Genetic Toxicology, Vol.300(2), pp.99-109
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0165-1218(93)90127-Y
- PMID
- 7685499
- ISSN
- 0165-1218
- eISSN
- 1873-135X
- Language
- English
- Date published
- 1993
- Academic Unit
- Pathology
- Record Identifier
- 9984083810502771
Metrics
11 Record Views