Genotype C of hepatitis B virus can be classified into at least two subgroups

Tran Thien-Tuan Huy; Hiroshi Ushijima; Vo Xuan Quang; Khin Maung Win; Pairoj Luengrojanakul; Kaoru Kikuchi; Tetsutaro Sata; Kenji Abe

doi:10.1099/vir.0.19633-0

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Genotype C of hepatitis B virus can be classified into at least two subgroups

Journal article

Open access

Peer reviewed

Genotype C of hepatitis B virus can be classified into at least two subgroups

Tran Thien-Tuan Huy, Hiroshi Ushijima, Vo Xuan Quang, Khin Maung Win, Pairoj Luengrojanakul, Kaoru Kikuchi, Tetsutaro Sata and Kenji Abe

Journal of general virology, Vol.85(Pt 2), pp.283-292

02/2004

DOI: 10.1099/vir.0.19633-0

PMID: 14769886

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Abstract

A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1/pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups.

Viral Envelope Proteins - genetics

Asia

Hepatitis B virus - classification

Humans

Genes, Viral

Hepatitis B virus - genetics

Databases, Genetic

Molecular Sequence Data

Hepatitis B virus - isolation & purification

Phylogeny

Gene Products, pol - genetics

Details

Title: Subtitle: Genotype C of hepatitis B virus can be classified into at least two subgroups
Creators: Tran Thien-Tuan Huy - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Hiroshi Ushijima - Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Vo Xuan Quang - Department of Gastroentero-Hepatology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Khin Maung Win - Department of Hepatology, Yangon General Hospital, Yangon, Myanmar
Pairoj Luengrojanakul - Department of Gastroenterology, Mahidol University Siriraj Hospital, Bangkok, Thailand
Kaoru Kikuchi - Gastroenterology Section, Okinawa Chubu Hospital, Okinawa, Japan
Tetsutaro Sata - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Kenji Abe - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Resource Type: Journal article
Publication Details: Journal of general virology, Vol.85(Pt 2), pp.283-292
DOI: 10.1099/vir.0.19633-0
PMID: 14769886
NLM abbreviation: J Gen Virol
ISSN: 0022-1317
eISSN: 1465-2099
Language: English
Date published: 02/2004
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094877702771

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