Journal article
Gentamicin/Collagen Sponge Use May Reduce the Risk of Surgical Site Infections for Patients Undergoing Cardiac Operations: A Meta-Analysis
Surgical Infections, Vol.15(3), pp.244-255
06/2014
DOI: 10.1089/sur.2012.209
PMCID: PMC4063378
PMID: 24773201
Abstract
Objective: A meta-analysis of all published randomized controlled trials of the effectiveness of gentamicin/collagen sponges for preventing surgical site infections (SSIs). Background: Despite routine use of systemic prophylactic antimicrobial agents, SSIs continue to be associated with substantial morbidity. Results conflict of studies of the efficacy of gentamicin/collagen sponges for preventing SSIs. However, many of these studies have assessed sponge use in only a single specific type of operation. The general effect of sponge use among different types of operations has not been previously assessed. Methods: The PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched for articles appearing from 1990 through January 2012 that were related to gentamicin/collagen sponge use and SSIs. Summary estimates were obtained through a random effects model. After reviewing 714 article abstracts and reviewing 22 articles in detail, we pooled the odds ratios (OR) for 13 independent study populations (cardiac, n=4; colorectal, n=4; pilonidal sinus, n=2; hernia, n=2; gastrointestinal, n=1) in which the association between prophylactic use of gentamicin/collagen sponges and SSIs was assessed. Results: Pooling of the results of all studies included in the review in a random effects model showed a significant protective effect of prophylactic use of gentamicin/collagen sponges against SSI (pooled OR: 0.66; 95% confidence interval [CI]: 0.45, 0.97; n=13). However, when the data were stratified by type of operation, a significant protective effect was observed in cardiac procedures (pooled OR: 0.59; 95% CI: 0.37, 0.96; n=4) but not in colorectal procedures (pooled OR: 0.74; 95% CI: 0.29–1.92; n=4). Conclusion: Use of gentamicin/collagen sponges was associated with a reduced risk of SSI following cardiac operations but not following colorectal procedures.
Details
- Title: Subtitle
- Gentamicin/Collagen Sponge Use May Reduce the Risk of Surgical Site Infections for Patients Undergoing Cardiac Operations: A Meta-Analysis
- Creators
- Michelle B Formanek - 2Center for Comprehensive Access and Delivery Research and Evaluation VA Health Care System, Iowa City, IowaLoreen A Herwaldt - 3Carver College of Medicine, University of Iowa, Iowa City, IowaEli N Perencevich - 3Carver College of Medicine, University of Iowa, Iowa City, IowaMarin L Schweizer - 3Carver College of Medicine, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Surgical Infections, Vol.15(3), pp.244-255
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/sur.2012.209
- PMID
- 24773201
- PMCID
- PMC4063378
- ISSN
- 1096-2964
- eISSN
- 1557-8674
- Language
- English
- Electronic publication date
- 04/28/2014
- Date published
- 06/2014
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983779295902771
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