Journal article
Geographic Origin and Vertical Transmission of Leishmania infantum Parasites in Hunting Hounds, United States
Emerging infectious diseases, Vol.28(6), pp.1211-1223
06/01/2022
DOI: 10.3201/eid2806.211746
PMCID: PMC9155895
PMID: 35608628
Abstract
Vertical transmission of leishmaniasis is common but is difficult to study against the background of pervasive vector transmission. We present genomic data from dogs in the United States infected with Leishmania infantum parasites; these infections have persisted in the apparent absence of vector transmission. We demonstrate that these parasites were introduced from the Old World separately and more recently than L. infantum from South America. The parasite population shows unusual genetics consistent with a lack of meiosis: a high level of heterozygous sites shared across all isolates and no decrease in linkage with genomic distance between variants. Our data confirm that this parasite population has been evolving with little or no sexual reproduction. This demonstration of vertical transmission has profound implications for the population genetics of Leishmania parasites. When investigating transmission in complex natural settings, considering vertical transmission alongside vector transmission is vital.
Details
- Title: Subtitle
- Geographic Origin and Vertical Transmission of Leishmania infantum Parasites in Hunting Hounds, United States
- Creators
- Susanne U. FranssenMandy J. SandersMatt BerrimanChristine A. PetersenJames A. Cotton
- Resource Type
- Journal article
- Publication Details
- Emerging infectious diseases, Vol.28(6), pp.1211-1223
- DOI
- 10.3201/eid2806.211746
- PMID
- 35608628
- PMCID
- PMC9155895
- NLM abbreviation
- Emerg Infect Dis
- ISSN
- 1080-6040
- eISSN
- 1080-6059
- Publisher
- Centers for Disease Control and Prevention
- Language
- English
- Date published
- 06/01/2022
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9984259160302771
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