Journal article
Geographic Variation in the Sensitivity of Recombinant Antigen-based Rapid Tests for Chronic Trypanosoma cruzi Infection
The American journal of tropical medicine and hygiene, Vol.80(3), pp.410-415
2009
DOI: 10.4269/ajtmh.2009.80.410
PMID: 19270291
Abstract
Chagas disease affects 8-11 million people throughout the Americas. Early detection is crucial for timely treatment and to prevent non-vectorial transmission. Recombinant antigen-based rapid tests had high sensitivity and specificity in laboratory evaluations, but no Peruvian specimens were included in previous studies. We evaluated Stat-Pak and Trypanosoma Detect rapid tests in specimens from Bolivia and Peru. Specimens positive by three conventional assays were confirmed positives; specimens negative by two or more assays were confirmed negatives. In Bolivian specimens, Stat-Pak and Trypanosoma Detect tests were 87.5% and 90.7% sensitive, respectively; both showed 100% specificity. Sensitivity in Peruvian specimens was much lower: 26.6-33.0% (Stat-Pak) and 54.3-55.2% (Trypanosoma Detect); both had specificities > 98%. Even in Bolivian specimens, these sensitivities are inadequate for stand-alone screening. The low sensitivity in Peru may be related to parasite strain differences. Chagas disease rapid tests should be field tested in each geographic site before widespread implementation for screening. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Details
- Title: Subtitle
- Geographic Variation in the Sensitivity of Recombinant Antigen-based Rapid Tests for Chronic Trypanosoma cruzi Infection
- Creators
- Jennifer R Verani - Centers for Disease Control and PreventionAmy Seitz - MS F-22Michael Z Levy - Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United StatesFrancis Steurer - Centers for Disease Control and PreventionCharles W Todd - MS F-22Louis V Kirchhoff - Centers for Disease Control and PreventionLilia Cabrera - MS F-22Manuela Verastegui - MS F-22Caryn Bern - Centers for Disease Control and PreventionRobert H Gilman - Centers for Disease Control and PreventionCarlos Lafuente - MS F-22Gerson GALDOS-CARDENAS - MS F-22Vivian Kawai - MS F-22Elizabeth DE LAFUENTE - MS F-22Lisbeth Ferrufino - MS F-22Natalie M Bowman - Infectious DiseasesViviana PINEDO-CANCINO - MS F-22
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.80(3), pp.410-415
- Publisher
- American Society of Tropical Medecine and Hygiene
- DOI
- 10.4269/ajtmh.2009.80.410
- PMID
- 19270291
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Language
- English
- Date published
- 2009
- Academic Unit
- Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984280832702771
Metrics
6 Record Views