Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis

Shawn R Lockhart; Shawn A Messer; Michael A Pfaller; Daniel J Diekema

doi:10.1128/JCM.00803-08

Back

Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis

Journal article

Open access

Peer reviewed

Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis

Shawn R Lockhart, Shawn A Messer, Michael A Pfaller and Daniel J Diekema

Journal of clinical microbiology, Vol.46(8), pp.2659-2664

08/2008

DOI: 10.1128/JCM.00803-08

PMCID: PMC2519489

PMID: 18562582

Files and links (1)

url

https://doi.org/10.1128/JCM.00803-08View

Published (Version of record) Open Access

Abstract

Candida orthopsilosis and Candida metapsilosis are recently described species, having previously been grouped with the more prevalent species Candida parapsilosis. Current literature contains very little data pertaining to the distributions and antifungal susceptibilities of these Candida species. We determined the species and antifungal susceptibilities of 1,929 invasive clinical isolates from the ARTEMIS antifungal surveillance program collected between 2001 and 2006 and identified as C. parapsilosis using Vitek and conventional methods. Of the 1,929 isolates of presumed C. parapsilosis tested, 117 (6.1%) were identified as C. orthopsilosis and 34 (1.8%) as C. metapsilosis. The percentage of presumed C. parapsilosis isolates found to be C. orthopsilosis varied greatly by region, with the highest percentage (10.9%) from South America and the lowest (0.7%) from Africa. The MIC distributions of the C. orthopsilosis and C. metapsilosis isolates were statistically significantly lower than those of C. parapsilosis for all drugs except fluconazole, for which they were significantly higher (P < 0.001 for all). No C. orthopsilosis or C. metapsilosis isolates were fluconazole resistant, and all were susceptible to caspofungin, anidulafungin, and micafungin.

Antifungal Agents - pharmacology

Geography

South America

Humans

Middle Aged

Africa

Child, Preschool

Infant

Candidiasis - microbiology

Candida - isolation & purification

Microbial Sensitivity Tests

Candida - classification

Adolescent

Aged, 80 and over

Adult

Aged

Candida - drug effects

Child

Drug Resistance, Fungal

Infant, Newborn

Details

Title: Subtitle: Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis
Creators: Shawn R Lockhart - Department of Pathology, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, 6008 BT GH, 200 Hawkins Drive, Iowa City, IA 52242-1009, USA. shawn-lockhart@uiowa.edu
Shawn A Messer
Michael A Pfaller
Daniel J Diekema
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.46(8), pp.2659-2664
DOI: 10.1128/JCM.00803-08
PMID: 18562582
PMCID: PMC2519489
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 08/2008
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986372302771

Metrics

20 Record Views

161 Times Cited - Web of Science