Journal article
Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program
Diagnostic microbiology and infectious disease, Vol.67(2), pp.162-171
2010
DOI: 10.1016/j.diagmicrobio.2010.01.002
PMID: 20338711
Abstract
Geographic differences in frequency and azole resistance among
Candida glabrata may impact empiric antifungal therapy choice. We examined geographic variation in isolation and azole susceptibility of
C. glabrata. We examined 23 305 clinical isolates of
C. glabrata during ARTEMIS DISK global surveillance. Susceptibility testing to fluconazole and voriconazole was assessed by disk diffusion, and the results were grouped by geographic location: North America (NA) (2470 isolates), Latin America (LA) (2039), Europe (EU) (12 439), Africa and the Middle East (AME) (728), and Asia-Pacific (AP) (5629). Overall,
C. glabrata accounted for 11.6% of 201 653 isolates of
Candida and varied as a proportion of all
Candida isolated from 7.4% in LA to 21.1% in NA. Decreased susceptibility (S) to fluconazole was observed in all geographic regions and ranged from 62.8% in AME to 76.7% in LA. Variation in fluconazole susceptibility was observed within each region: AP (range, 50–100% S), AME (48–86.9%), EU (44.8–88%), LA (43–92%), and NA (74.5–91.6%). Voriconazole was more active than fluconazole (range, 82.3–84.2% S) with similar regional variation. Among 22 sentinel sites participating in ARTEMIS from 2001 through 2007 (84 140 total isolates, 8163
C. glabrata), the frequency of
C. glabrata isolation increased in 14 sites and the frequency of fluconazole resistance (R) increased in 11 sites over the 7-year period of study. The sites with the highest cumulative rates of fluconazole R were in Poland (22% R), the Czech Republic (27% R), Venezuela (27% R), and Greece (33% R).
C. glabrata was most often isolated from blood, normally sterile body fluids and urine. There is substantial geographic and institutional variation in both frequency of isolation and azole resistance among
C. glabrata. Prompt species identification and fluconazole susceptibility testing are necessary to optimize therapy for invasive candidiasis.
Details
- Title: Subtitle
- Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program
- Creators
- Michael A Pfaller - University of Iowa Carver College of Medicine, Iowa City, IA 52242, USADaniel J Diekema - University of Iowa Carver College of Medicine, Iowa City, IA 52242, USADavid L Gibbs - Giles Scientific, Inc., Santa Barbara, CA 93103, USAVance A Newell - Giles Scientific, Inc., Santa Barbara, CA 93103, USARichard Barton - General Infirmary, P.H.L.S., Leeds LS1 3EX, UKHu Bijie - Zhong Shan Hospital, Shanghai 200032, ChinaJacques Bille - Institute of Microbiology, CHUV, Lausanne, SwitzerlandShan-Chwen Chang - National Taiwan University Hospital, Taipei, TaiwanMaria da Luz Martins - Instituto de Higiene de Medicina Tropical, Lisboa 1349-008, PortugalAdriano Duse - WITJ University, Johannesburg, South AfricaDanuta Dzierzanowska - Children's Memorial Health Institute, Warsaw, PolandDavid Ellis - Womens and Children's Hospital, North Adelaide SA 5006, AustraliaJorge Finquelievich - Centro de Micologia, Buenos Aires, ArgentinaIan Gould - Aberdeen Royal Hospital, Aberdeen, Aberdeen City AB25 2, UKDeniz Gur - Hacettepe University—Children's Hospital, Ankara, TurkeyAnwar Hoosen - Ga-Rankuwa Hospital, Medunsa 0204, South AfricaKyungwon Lee - Yonsei University College of Medicine, Seoul 120-752, South KoreaNada Mallatova - Hospital Ceske Budejovice, Ceske, Czech RepublicMichele Mallie - Faculte de Pharmacie, 34060 Montpellier, FranceNG Kee Peng - University Malaya, 50603 Kuala Lumpur, MalaysiaGeorge Petrikos - Laikon General Hospital, Athens 11527, GreeceAxel Santiago - Universitario de Caracas, Caracas, VenezuelaJan Trupl - SYNLAB s.r.o., Bratislava, Slovak RepublicAnn Marie VanDen Abeele - St. Lucas Campus Heilige Familie, Gent, BelgiumJeannette Wadula - Baragwanath Hospital, Johannesburg 2013, South AfricaMussaret Zaidi - Hospital General O'Horan, Merida 97000, Mexicothe Global Antifungal Surveillance Group
- Contributors
- Global Antifungal Surveillance Group (Author)
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.67(2), pp.162-171
- DOI
- 10.1016/j.diagmicrobio.2010.01.002
- PMID
- 20338711
- NLM abbreviation
- Diagn Microbiol Infect Dis
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2010
- Academic Unit
- Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986262202771
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