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Germline mosaic transmission of a novel duplication of PXDN and MYT1L to two male half-siblings with autism
Journal article   Peer reviewed

Germline mosaic transmission of a novel duplication of PXDN and MYT1L to two male half-siblings with autism

Kacie J Meyer, Michael S Axelsen, Val C Sheffield, Shivanand R Patil and Thomas H Wassink
Psychiatric genetics, Vol.22(3), pp.137-140
06/2012
DOI: 10.1097/YPG.0b013e32834dc3f5
PMCID: PMC3309069
PMID: 22157634

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Abstract

Autism is a neurodevelopmental disorder with a strong genetic component to susceptibility. In this study, we report the molecular characterization of an apparent de-novo 281 kb duplication of chromosome 2p25.3 in two male half-siblings with autism. The 2p25.3 duplication was first identified through a low-density microarray, validated with fluorescent in-situ hybridization, and duplication breakpoints were delineated using an Affymetrix 6.0 single-nucleotide polymorphism microarray. The fluorescent in-situ hybridization results validated the novel copy number variant and revealed the mother to be mosaic, with ∼33% of her lymphoblast cells carrying the duplication. Therefore, the duplication was transmitted through the mechanism of germline mosaicism. In addition, duplication breakpoints were refined and showed that PXDN is fully duplicated, whereas seven exons of the terminal portion of the 25 exon gene MYT1L are within the duplicated region. MYT1L, a gene predominately expressed in the brain, has recently been linked with other neuropsychiatric illness such as schizophrenia and depression. Results from this study indicate that the 2p25.3 duplication disrupting PXDN and MYT1L is a potential autism-causing variant in the pedigree reported here and should receive further consideration as a candidate for autism.
Autistic Disorder - genetics Chromosomes, Human, Pair 2 Gene Duplication Humans Germ-Line Mutation In Situ Hybridization, Fluorescence Male Mosaicism Transcription Factors - genetics Nerve Tissue Proteins - genetics

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