Journal article
Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels
FEMS yeast research, Vol.16(3), p.fow019
05/01/2016
DOI: 10.1093/femsyr/fow019
PMCID: PMC5731434
PMID: 26926495
Abstract
Cardiolipin (CL) is the signature phospholipid of mitochondrial membranes. CL deficiency leads to defects in mitochondrial function. Using a targeted synthetic lethality screen to identify defects that exacerbate CL deficiency, we determined that deletion of mitochondrial morphology genes in cells lacking CL leads to severe growth defects. We show that ER membrane proteins Get1p and Get2p are required for maintaining normal levels of CL. We propose that these proteins regulate the level of CL by maintaining wild type-like tubular mitochondrial morphology. The genetic interactions observed in this study identify novel physiological modifiers that are required for maintenance of CL levels and mitochondrial morphology.
Details
- Title: Subtitle
- Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels
- Creators
- Amit S. Joshi - Wayne State UniversityNaomi Fei - Wayne State UniversityMiriam L. Greenberg - Wayne State University
- Resource Type
- Journal article
- Publication Details
- FEMS yeast research, Vol.16(3), p.fow019
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/femsyr/fow019
- PMID
- 26926495
- PMCID
- PMC5731434
- ISSN
- 1567-1356
- eISSN
- 1567-1364
- Number of pages
- 6
- Grant note
- RO1 HL 117880 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Barth Syndrome Foundation R01HL062263 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) WSU
- Language
- English
- Date published
- 05/01/2016
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359937002771
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