Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits

Laura Boles Ponto; Vincent Magnotta; David Moser; Kevin Duff; Susan Schultz

doi:10.1007/s11307-006-0066-z

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Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits

Journal article

Peer reviewed

Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits

Laura Boles Ponto, Vincent Magnotta, David Moser, Kevin Duff and Susan Schultz

Molecular imaging and biology, Vol.8(6), pp.363-372

11/2006

DOI: 10.1007/s11307-006-0066-z

PMID: 17048070

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Abstract

This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET).Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62–84, 71.8 ± 6.2 years) meeting criteria for mild cognitive impairment (MCI). PET consisted of quantitative [15O]water determinations of CBF, two at baseline and one postadministration of acetazolamide (ACZ).Mean gCBF were 44.9 ± 5.5 during counting, 44.5 ± 6.7 for the memory task, and 60.2 ± 4.8 ml/min/100 g for post-ACZ (CVR of 33.9 ± 13.2%). Task-related gCBF change was significantly related to memory score, performance on the Trail Making Test B (Trails-B), premorbid IQ, and education, and differed significantly between the learning-based groups.Cognitive reserve appears analogous to cardiac reserve. The ability to alter gCBF paralleled performance on general cognitive measures, was enhanced in higher levels of cognitive reserve, and was impaired in individuals who no longer appear to benefit from repeated exposure to testing.

Cognitive reserve

Cerebrovascular reserve

Medicine & Public Health

Mild cognitive impairment

[ 15 O]water

Imaging / Radiology

Global cerebral blood flow

Details

Title: Subtitle: Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits
Creators: Laura Boles Ponto - PET Imaging Center 0911 Z JPP, University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa IA 52242 USA
Vincent Magnotta - Positron Emission Tomography Imaging Center, Department of Radiology, Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 USA
David Moser - Positron Emission Tomography Imaging Center, Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 USA
Kevin Duff - Positron Emission Tomography Imaging Center, Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 USA
Susan Schultz - Positron Emission Tomography Imaging Center, Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 USA
Resource Type: Journal article
Publication Details: Molecular imaging and biology, Vol.8(6), pp.363-372
DOI: 10.1007/s11307-006-0066-z
PMID: 17048070
NLM abbreviation: Mol Imaging Biol
ISSN: 1536-1632
eISSN: 1860-2002
Publisher: Springer-Verlag; New York
Language: English
Date published: 11/2006
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicine Administration; Internal Medicine
Record Identifier: 9984003922102771

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