Global cerebral blood flow after CO2 inhalation in normal subjects and patients with panic disorder determined with [15O]water and PET

Laura L Boles Ponto; Roger G Kathol; Richard Kettelkamp; G Leonard Watkins; John C W Richmond; Jo Clark; Richard D Hichwa

doi:10.1016/S0887-6185(02)00094-4

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Global cerebral blood flow after CO2 inhalation in normal subjects and patients with panic disorder determined with [15O]water and PET

Journal article

Peer reviewed

Global cerebral blood flow after CO2 inhalation in normal subjects and patients with panic disorder determined with [15O]water and PET

Laura L Boles Ponto, Roger G Kathol, Richard Kettelkamp, G Leonard Watkins, John C W Richmond, Jo Clark and Richard D Hichwa

Journal of anxiety disorders, Vol.16(3), pp.247-258

2002

DOI: 10.1016/S0887-6185(02)00094-4

PMID: 12214811

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Abstract

To determine the effect of CO2 inhalation on global cerebral blood flow (gCBF) and pCO2-adjusted gCBF in normal subjects and panic disorder patients. Global cerebral blood flow was determined using quantitative [15O] water imaging in normal subjects (n = 12) and panic disorder patients (n = 14) after inhalations of medical grade air and of 35%/65% CO2/O2 mixture, a known inducer of panic. The gCBF was calculated as an area-weighted mean value. The pCO2 -adjusted gCBF values were calculated based on the formula of Reiman et al. [Am. J. Psychiatr. 143 (1986) 469]. Data were analyzed using repeated-measures ANOVA and regression analyses. The pCO2 values did not differ statistically between normals and panic patients. Panic patients exhibited a decrease in gCBF and stable pCO2-adjusted gCBF values in comparisons of AIR and CO2 inhalations, whereas normals exhibited stable gCBF and increasing pCO2-adjusted gCBF values. Patients with panic disorder, especially when symptomatic, exhibited an abnormal pattern in gCBF response to provocation.

Water

Oxygen Radioisotopes

Analysis of Variance

Cerebrovascular Circulation - physiology

Humans

Adult

Carbon Dioxide - administration & dosage

Female

Male

Panic Disorder - physiopathology

Panic Disorder - diagnostic imaging

Tomography, Emission-Computed

Details

Title: Subtitle: Global cerebral blood flow after CO2 inhalation in normal subjects and patients with panic disorder determined with [15O]water and PET
Creators: Laura L Boles Ponto - Department of Radiology, PET Imaging Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA. laura-ponto@uiowa.edu
Roger G Kathol
Richard Kettelkamp
G Leonard Watkins
John C W Richmond
Jo Clark
Richard D Hichwa
Resource Type: Journal article
Publication Details: Journal of anxiety disorders, Vol.16(3), pp.247-258
Publisher: Netherlands
DOI: 10.1016/S0887-6185(02)00094-4
PMID: 12214811
ISSN: 0887-6185
eISSN: 1873-7897
Language: English
Date published: 2002
Academic Unit: Radiology; Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984051893202771

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