Journal article
Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
Science advances, Vol.4(10), pp.eaat5869-eaat5869
10/2018
DOI: 10.1126/sciadv.aat5869
PMCID: PMC6192687
PMID: 30345355
Abstract
On the basis of population genomic and phylogeographic analyses of 1669
lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.
Details
- Title: Subtitle
- Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
- Creators
- Ola B Brynildsrud - Norwegian Institute of Public HealthCaitlin S Pepperell - University of Wisconsin–MadisonPhilip Suffys - MRC Laboratory of Molecular BiologyLouis Grandjean - Imperial College LondonJohana Monteserin - Consejo Nacional de Investigaciones Científicas y TécnicasNadia Debech - Norwegian Institute of Public HealthJon Bohlin - Norwegian Institute of Public HealthKristian Alfsnes - Norwegian Institute of Public HealthJohn O-H Pettersson - Norwegian Institute of Public HealthIngerid Kirkeleite - Norwegian Institute of Public HealthFatima Fandinho - Laboratorio de Bacteriologia da Tuberculose, Centro de Referłncia Professor Helio Fraga-Jacarepagu, Estrada de Curicica 2000, Brazil.Marcia Aparecida da Silva - Laboratorio de Bacteriologia da Tuberculose, Centro de Referłncia Professor Helio Fraga-Jacarepagu, Estrada de Curicica 2000, Brazil.Joao Perdigao - University of LisbonIsabel Portugal - University of LisbonMiguel Viveiros - Universidade Nova de LisboaTaane Clark - University of LondonMaxine Caws - Liverpool School of Tropical MedicineSarah Dunstan - University of MelbournePhan Vuong Khac Thai - Pham Ngoc Thach HospitalBeatriz Lopez - Instituto Nacional de Enfermedades Infecciosas, ANLIS Carlos Malbran, Buenos Aires, Argentina.Viviana Ritacco - Consejo Nacional de Investigaciones Científicas y TécnicasAndrew Kitchen - University of IowaTyler S Brown - Harvard UniversityDick van Soolingen - Center for Infectious Disease ResearchMary B O'Neill - University of Wisconsin–MadisonKathryn E Holt - University of MelbourneEdward J Feil - University of BathBarun Mathema - Columbia UniversityFrancois Balloux - University College LondonVegard Eldholm - Norwegian Institute of Public Health
- Resource Type
- Journal article
- Publication Details
- Science advances, Vol.4(10), pp.eaat5869-eaat5869
- DOI
- 10.1126/sciadv.aat5869
- PMID
- 30345355
- PMCID
- PMC6192687
- ISSN
- 2375-2548
- eISSN
- 2375-2548
- Grant note
- R01 AI113287 / NIAID NIH HHS MR/P007597/1 / Medical Research Council
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Anthropology; International Programs
- Record Identifier
- 9984269244702771
Metrics
13 Record Views