Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu; Catherine Bisignano; Spencer L. James; Gdiom Gebreheat Abady; Aidin Abedi; Eman Abu-Gharbieh; Robert Kaba Alhassan; Vahid Alipour; Jalal Arabloo; Malke Asaad; Wondwossen Niguse Asmare; Atalel Fentahun Awedew; Maciej Banach; Srikanta K. Banerjee; Ali Bijani; Tesega Tesega Mengistu Birhanu; Srinivasa Rao Bolla; Luis Alberto Camera; Jung-Chen Chang; Daniel Youngwhan Cho; Michael T. Chung; Rosa A. S. Couto; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Farshad Farzadfar; Irina Filip; Florian Fischer; Artem Alekseevich Fomenkov; Tiffany K. Gill; Bhawna Gupta; Juanita A. Haagsma; Arvin Haj-Mirzaian; Samer Hamidi; Simon Hay; Irena M. Ilic; Milena D. Ilic; Rebecca Q. Ivers; Mikk Jurisson; Rohollah Kalhor; Tanuj Kanchan; Taras Kavetskyy; Rovshan Khalilov; Ejaz Ahmad Khan; Maseer Khan; Cameron J. Kneib; Vijay Krishnamoorthy; G. Anil Kumar; Narinder Kumar; Ratilal Lalloo; Savita Lasrado; Stephen S. Lim; Zichen Liu; Ali Manafi; Navid Manafi; Ritesh G. Menezes; Tuomo J. Meretoja; Bartosz Miazgowski; Ted R. Miller; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Ali H. Mokdad; Christopher J. L. Murray; Mehdi Naderi; Mukhammad David Naimzada; Vinod C. Nayak; Cuong Tat Nguyen; Rajan Nikbakhsh; Andrew T. Olagunju; Nikita Otstavnov; Stanislav S. Otstavnov; Jagadish Rao Padubidri; Jeevan Pereira; Hai Quang Pham; Marina Pinheiro; Suzanne Polinder; Hadis Pourchamani; Navid Rabiee; Amir Radfar; Mohammad Hifz Ur Rahman; David Laith Rawaf; Salman Rawaf; Mohammad Reza Saeb; Abdallah M. Samy; Lidia Sanchez Riera; David C. Schwebel; Saeed Shahabi; Masood Ali Shaikh; Amin Soheili; Rafael Tabares-Seisdedos; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Ravensara S. Travillian; Pascual R. Valdez; Tommi Juhani Vasankari; Diana Zuleika Velazquez; Narayanaswamy Venketasubramanian; Giang Thu Vu; Zhi-Jiang Zhang; Theo Vos; GBD 2019 Fracture Collaborators

doi:10.1016/S2666-7568(21)00172-0

$Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019$

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Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu, Catherine Bisignano, Spencer L. James, Gdiom Gebreheat Abady, Aidin Abedi, Eman Abu-Gharbieh, Robert Kaba Alhassan, Vahid Alipour, Jalal Arabloo, Malke Asaad, …

The Lancet. Healthy longevity, Vol.2(9), pp.E580-E592

09/01/2021

DOI: 10.1016/S2666-7568(21)00172-0

PMCID: PMC8547262

PMID: 34723233

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Abstract

Background Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings Globally, in 2019, there were 178 million (95% UI 162-196) new fractures (an increase of 33.4% [30.1-37.0] since 1990), 455 million (428-484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70.1% [67.5-72.5] since 1990), and 25.8 million (17.8-35.8) YLDs (an increase of 65.3% [62.4-68.0] since 1990). The age-standardised rates of fractures in 2019 were 2296.2 incident cases (2091.1-2529.5) per 100 000 population (a decrease of 9.6% [8.1-11.1] since 1990), 5614.3 prevalent cases (5286.1-5977.5) per 100 000 population (a decrease of 6.7% [5.7-7.6] since 1990), and 319.0 YLDs (220.1-442.5) per 100 000 population (a decrease of 8.4% [7.2-9.5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419.9 cases (345.8-512.0) per 100 000 population and an age-standardised rate of YLDs of 190.4 (125.0-276.9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381.5 incident cases (11 245.3-20 651.9) per 100 000 population in those aged 95 years and older. Interpretation The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.

Geriatrics & Gerontology

Life Sciences & Biomedicine

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Title: Subtitle: Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019
Creators: Ai-Min Wu - Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Zhejiang Prov Key Lab Orthopaed, Dept Orthopaed, Wenzhou 325027, Peoples R China
Catherine Bisignano - University of Washington
Spencer L. James - Genentech
Gdiom Gebreheat Abady - Adigrat University
Aidin Abedi - Univ Southern Calif, Dept Orthopaed Surg, Los Angeles, CA 90007 USA
Eman Abu-Gharbieh - University of Sharjah
Robert Kaba Alhassan - Univ Hlth & Allied Sci, Inst Hlth Res, Ho, Ghana
Vahid Alipour - Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran
Jalal Arabloo - Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran
Malke Asaad - Univ Texas Houston, Dept Plast Surg, Houston, TX USA
Wondwossen Niguse Asmare - MizanTepi Univ, Dept Nursing, Mizan Teferi, Ethiopia
Atalel Fentahun Awedew - Addis Ababa University
Maciej Banach - Med Univ Lodz, Dept Hypertens, Lodz, Poland
Srikanta K. Banerjee - Walden University
Ali Bijani - Babol Univ Med Sci, Social Determinants Hlth Res Ctr, Babol, Iran
Tesega Tesega Mengistu Birhanu - Amhara Publ Hlth Inst, Planning Monitoring & Evaluat Directorate, Bahir Dar, Ethiopia
Srinivasa Rao Bolla - Nazarbayev University
Luis Alberto Camera - Hosp Italiano Buenos Aires, Internal Med Dept, Buenos Aires, DF, Argentina
Jung-Chen Chang - Natl Taiwan Univ, Coll Med, Taipei, Taiwan
Daniel Youngwhan Cho - University of Washington
Michael T. Chung - Wayne State University
Rosa A. S. Couto - Univ Porto, Dept Chem Sci, Porto, Portugal
Xiaochen Dai - University of Washington
Lalit Dandona - University of Washington
Rakhi Dandona - University of Washington
Farshad Farzadfar - University of Tehran
Irina Filip - Kaiser Permanente
Florian Fischer - Ravensburg Weingarten Univ Appl Sci, Inst Gerontol Hlth Serv & Nursing Res, Weingarten, Germany
Artem Alekseevich Fomenkov - KA Timiryazev Inst Plant Physiol, Dept Cell Biol & Biotechnol, Moscow, Russia
Tiffany K. Gill - The University of Adelaide
Bhawna Gupta - The University of Melbourne
Juanita A. Haagsma - Erasmus MC
Arvin Haj-Mirzaian - University of Tehran
Samer Hamidi - Hamdan Bin Mohammed Smart University
Simon Hay - University of Washington
Irena M. Ilic - University of Belgrade
Milena D. Ilic - University of Kragujevac
Rebecca Q. Ivers - UNSW Sydney
Mikk Jurisson - University of Tartu
Rohollah Kalhor - Qazvin Univ Med Sci, Inst Prevent Noncommunicable Dis, Qazvin, Iran
Tanuj Kanchan - All India Inst Med Sci, Dept Forens Med & Toxicol, Jodhpur, Rajasthan, India
Taras Kavetskyy - John Paul II Catholic University of Lublin
Rovshan Khalilov - Baku State University
Ejaz Ahmad Khan - Hlth Serv Acad, Dept Epidemiol & Biostat, Islamabad, Pakistan
Maseer Khan - Jazan University
Cameron J. Kneib - University of Washington
Vijay Krishnamoorthy - University of Washington
G. Anil Kumar - Publ Hlth Fdn India, Gurugram, India
Narinder Kumar - Medanta Hosp, Dept Orthopaed, Lucknow, Uttar Pradesh, India
Ratilal Lalloo - The University of Queensland
Savita Lasrado - Father Muller Med Coll, Dept Otorhinolaryngol, Mangalore, India
Stephen S. Lim - University of Washington
Zichen Liu - University of Washington
Ali Manafi - Iran Univ Med Sci, Plast Surg Dept, Tehran, Iran
Navid Manafi - Iran Univ Med Sci, Sch Med, Tehran, Iran
Ritesh G. Menezes - Imam Abdulrahman Bin Faisal University
Tuomo J. Meretoja - Helsinki Univ Hosp, Breast Surg Unit, Helsinki, Finland
Bartosz Miazgowski - Pomeranian Med Univ, Ctr Innovat Med Educ, Szczecin, Poland
Ted R. Miller - Pacific Inst Res & Evaluat, Calverton, MD USA
Yousef Mohammad - King Saud University
Abdollah Mohammadian-Hafshejani - Shahrekord University
Ali H. Mokdad - University of Washington
Christopher J. L. Murray - University of Washington
Mehdi Naderi - Kermanshah Univ Med Sci, Clin Res Dev Ctr, Kermanshah, Iran
Mukhammad David Naimzada - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Vinod C. Nayak - Manipal Acad Higher Educ, Dept Forens Med & Toxicol, Manipal, Karnataka, India
Cuong Tat Nguyen - Duy Tan University
Rajan Nikbakhsh - Shahid Beheshti University
Andrew T. Olagunju - McMaster University
Nikita Otstavnov - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Stanislav S. Otstavnov - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Jagadish Rao Padubidri - Manipal Acad Higher Educ, Kasturba Med Coll, Manipal, Karnataka, India
Jeevan Pereira - Yenepoya University
Hai Quang Pham - Duy Tan University
Marina Pinheiro - Univ Porto, Dept Chem, Porto, Portugal
Suzanne Polinder - Erasmus MC
Hadis Pourchamani - Kermanshah Univ Med Sci, Clin Res Dev Ctr, Kermanshah, Iran
Navid Rabiee - Sharif University of Technology
Amir Radfar - Univ Cent Florida, Coll Med, Orlando, FL USA
Mohammad Hifz Ur Rahman - Maharishi Markandeshwar Med Coll & Hosp, Dept Community Med, Solan, India
David Laith Rawaf - Imperial Coll London, WHO Collaborating Ctr Publ Hlth Educ & Training, London, England
Salman Rawaf - Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
Mohammad Reza Saeb - Supélec
Abdallah M. Samy - Ain Shams University
Lidia Sanchez Riera - Avon
David C. Schwebel - University of Alabama
Saeed Shahabi - Shiraz University
Masood Ali Shaikh
Amin Soheili - Semnan University
Rafael Tabares-Seisdedos - Univ Valencia, Dept Med, Valencia, Spain
Marcos Roberto Tovani-Palone - Univ Sao Paulo, Dept Pathol & Legal Med, Ribeirao Preto, Brazil
Bach Xuan Tran - Hanoi Med Univ, Dept Hlth Econ, Hanoi, Vietnam
Ravensara S. Travillian - University of Washington
Pascual R. Valdez - Velez Sarsfield Hosp, Buenos Aires, DF, Argentina
Tommi Juhani Vasankari - Urho Kaleva Kekkonen Institute
Diana Zuleika Velazquez - Universidad Autónoma de Sinaloa
Narayanaswamy Venketasubramanian - Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore
Giang Thu Vu - Trường ĐH Nguyễn Tất Thành
Zhi-Jiang Zhang - Wuhan University
Theo Vos - University of Washington
GBD 2019 Fracture Collaborators
Resource Type: Journal article
Publication Details: The Lancet. Healthy longevity, Vol.2(9), pp.E580-E592
DOI: 10.1016/S2666-7568(21)00172-0
PMID: 34723233
PMCID: PMC8547262
NLM abbreviation: Lancet Healthy Longev
ISSN: 2666-7568
eISSN: 2666-7568
Publisher: Elsevier
Number of pages: 13
Grant note: 075-15-2019-1882 / Megagrant project Walden University Social Change Grant Egyptian Fulbright Mission Program
Language: English
Date published: 09/01/2021
Academic Unit: Research Administration
Record Identifier: 9984949191102771

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