Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study

Tonya White; Vincent A Magnotta; H Jeremy Bockholt; Sumner Williams; Stuart Wallace; Stefan Ehrlich; Bryon A Mueller; Beng-Choon Ho; Rex E Jung; Vincent P Clark; John Lauriello; Juan R Bustillo; S Charles Schulz; Randy L Gollub; Nancy C Andreasen; Vince D Calhoun; Kelvin O Lim

doi:10.1093/schbul/sbp088

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Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study

Journal article

Open access

Peer reviewed

Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study

Tonya White, Vincent A Magnotta, H Jeremy Bockholt, Sumner Williams, Stuart Wallace, Stefan Ehrlich, Bryon A Mueller, Beng-Choon Ho, Rex E Jung, Vincent P Clark, …

Schizophrenia bulletin, Vol.37(1), pp.222-232

01/2011

DOI: 10.1093/schbul/sbp088

PMCID: PMC3004177

PMID: 19770491

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https://pmc.ncbi.nlm.nih.gov/articles/PMC3004177/View

Published (Version of record) Open Access

Abstract

Emerging evidence implicates white matter (WM) abnormalities in the pathophysiology of schizophrenia. However, there is considerable heterogeneity in the presentation of WM abnormalities in the existing studies. The object of this study was to evaluate WM integrity in a large sample of patients with first-episode (FE) and chronic schizophrenia in comparison to matched control groups. Our goal was to assess whether WM findings occurred early in the illness or whether these abnormalities developed with the illness over time. Participants included 114 patients with schizophrenia (31 FE and 83 chronic patients) and 138 matched controls. High-resolution structural and diffusion tensor images were obtained on all participants. Measures of fractional anisotropy (FA) were calculated for the 4 cortical lobes and the cerebellum and brain stem. FA was significant lower in patients vs controls in the whole brain and individually in the frontal, parietal, occipital, and temporal lobes. FA was not significantly different in the brain stem or cerebellum. FA differences were significant only in patients with chronic schizophrenia and not in the FE group. We found global differences in the WM microstructure in patients with chronic but not FE schizophrenia. These findings suggest progressive alterations in WM microstructure.

Image Processing, Computer-Assisted

Humans

Middle Aged

Brain - pathology

Adult

Female

Male

Schizophrenia - pathology

Temporal Lobe - pathology

Case-Control Studies

Frontal Lobe - pathology

Diffusion Tensor Imaging

Details

Title: Subtitle: Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study
Creators: Tonya White - Department of Child and Adolescent Psychiatry, Erasmus University, 3000 CB Rotterdam, the Netherlands. t.white@erasmusmc.nl
Vincent A Magnotta
H Jeremy Bockholt
Sumner Williams
Stuart Wallace
Stefan Ehrlich
Bryon A Mueller
Beng-Choon Ho
Rex E Jung
Vincent P Clark
John Lauriello
Juan R Bustillo
S Charles Schulz
Randy L Gollub
Nancy C Andreasen
Vince D Calhoun
Kelvin O Lim
Resource Type: Journal article
Publication Details: Schizophrenia bulletin, Vol.37(1), pp.222-232
DOI: 10.1093/schbul/sbp088
PMID: 19770491
PMCID: PMC3004177
NLM abbreviation: Schizophr Bull
ISSN: 0586-7614
eISSN: 1745-1701
Publisher: United States
Grant note: P30NS057091 / NINDS NIH HHS K08 MH068540 / NIMH NIH HHS U24 RR021382 / NCRR NIH HHS UL1 RR024979 / NCRR NIH HHS P41 RR00807 / NCRR NIH HHS NS050568 / NINDS NIH HHS
Language: English
Date published: 01/2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003998602771

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